ArticleFrontiers in neurology2012
Genetics of frontotemporal lobar degeneration.
Article in Frontiers in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Atypical Frontotemporal Dementia Associated With SQSTM1 Gene Mutation: A Clinicopathological Case.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025Article
- Automated brain segmentation and volumetry in dementia diagnostics: a narrative review with emphasis on FreeSurfer.Frontiers in aging neuroscience · 2024Review
- Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.Communications biology · 2022Article
- The Expanding Regulatory Mechanisms and Cellular Functions of Long Non-coding RNAs (lncRNAs) in Neuroinflammation.Molecular neurobiology · 2021Review
- Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.Scientific reports · 2019Article
- Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.Cold Spring Harbor perspectives in biology · 2018Review
- The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry.Journal of neurology, neurosurgery, and psychiatry · 2016Review
- The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia.American journal of Alzheimer's disease and other dementias · 2015Article
- Interactions between traumatic brain injury and frontotemporal degeneration.Dementia and geriatric cognitive disorders · 2015Article
- Identification of the PS1 Thr147Ile Variant in a Family with Very Early Onset Dementia and Expressive Aphasia.Journal of Alzheimer's disease : JAD · 2015Article
- A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.Journal of neuropathology and experimental neurology · 2014Article
- Positive florbetapir PET amyloid imaging in a subject with frequent cortical neuritic plaques and frontotemporal lobar degeneration with TDP43-positive inclusions.Journal of Alzheimer's disease : JAD · 2014Article
- MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.Neural regeneration research · 2013Article
- The genetics of dementia.Seminars in neurology · 2013Article
- Mechanisms of granulin deficiency: lessons from cellular and animal models.Molecular neurobiology · 2013Review
- Progress in frontotemporal dementia research.American journal of Alzheimer's disease and other dementias · 2013Review
- A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function.PloS one · 2013Article
- Cognitive impairment and dementia in Parkinson's disease: clinical features, diagnosis, and management.Frontiers in neurology · 2012Article
- Cognitive impairment and dementia-an update.Frontiers in neurology · 2012Article
- Analysis of a case series of behavioral variant frontotemporal dementia: emphasis on diagnostic delay.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frontotemporal lobar degeneration (FTLD), the most frequent neurodegenerative disorder with a presenile onset, presents with a spectrum of clinical manifestations, ranging from behavioral and executive impairment to language disorders and motor dysfunction. Familial aggregation is frequently reported, and about 10% of cases have an autosomal dominant transmission. Microtubule associated protein tau (MAPT) gene mutations have been the first ones identified and are associated with early onset behavioral variant frontotemporal dementia phenotype. More recently, progranulin gene (GRN) mutations were recognized in association with familial form of FTLD. In addition, other genes are linked to rare cases of familial FTLD. Lastly, a number of genetic risk factors for sporadic forms have also been identified. In this review, current knowledge about mutations at the basis of familial FTLD will be described, together with genetic risk factors influencing the susceptibility to FTLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.