ArticleFrontiers in physiology2012
Nitric oxide synthases and atrial fibrillation.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The role of nitric oxide in hypertensive target organ damage in patients without renal impairment: insights from left ventricular global longitudinal strain and albuminuria.BMC cardiovascular disorders · 2026Article
- An Exogenous NO Donor Provokes Mechanical Alternans in Normal Rat Atria and Impairs Sarcomere Contractility in Right Atrial Cardiomyocytes in Atrial Fibrillation.Biomolecules · 2025Article
- Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.iScience · 2024Article
- Gene Polymorphism and Recurrent Atrial Fibrillation after Catheter Ablation: A Comprehensive Review.Reviews in cardiovascular medicine · 2023Review
- The inter-chamber differences in the contractile function between left and right atrial cardiomyocytes in atrial fibrillation in rats.Frontiers in cardiovascular medicine · 2023Article
- Lowering serum homocysteine in H-type hypertensive patients with atrial fibrillation after radiofrequency catheter ablation to prevent atrial fibrillation recurrence.Frontiers in nutrition · 2022Article
- Metabolic Signature of Arrhythmogenic Cardiomyopathy.Metabolites · 2021Article
- Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications.International journal of molecular sciences · 2020Review
- Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats.Frontiers in physiology · 2019Article
- Diabetes and Arrhythmias: Pathophysiology, Mechanisms and Therapeutic Outcomes.Frontiers in physiology · 2018Review
- Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.Stroke · 2017Article
- Perspectives and challenges of antioxidant therapy for atrial fibrillation.Naunyn-Schmiedeberg's archives of pharmacology · 2017Review
- Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.American heart journal · 2015Article
- Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.Life sciences · 2015Article
- Mitochondrial DNA 4977bp deletion mutation in peripheral blood reflects atrial remodeling in patients with non-valvular atrial fibrillation.Yonsei medical journal · 2015Article
- Oxidative stress as a mechanism of added sugar-induced cardiovascular disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2014Review
- Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.PloS one · 2014Article
- Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural/electrical remodeling.International journal of cardiology · 2013Review
- Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.Journal of cardiovascular pharmacology · 2013Article
- Atrial fibrillation in the elderly: the potential contribution of reactive oxygen species.Journal of geriatric cardiology : JGC · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Oxidative stress has been implicated in the pathogenesis of atrial fibrillation. There are multiple systems in the myocardium which contribute to redox homeostasis, and loss of homeostasis can result in oxidative stress. Potential sources of oxidants include nitric oxide synthases (NOS), which normally produce nitric oxide in the heart. Two NOS isoforms (1 and 3) are normally expressed in the heart. During pathologies such as heart failure, there is induction of NOS 2 in multiple cell types in the myocardium. In certain conditions, the NOS enzymes may become uncoupled, shifting from production of nitric oxide to superoxide anion, a potent free radical and oxidant. Multiple lines of evidence suggest a role for NOS in the pathogenesis of atrial fibrillation. Therapeutic approaches to reduce atrial fibrillation by modulation of NOS activity may be beneficial, although further investigation of this strategy is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.