ArticleThe Journal of infectious diseases2012
Nontypeable pneumococcal isolates among navajo and white mountain apache communities: are these really a cause of invasive disease?
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Prevalence, Antimicrobial Resistance, and Genetic Diversity of Non-TypeableHealth science reports · 2026Review
- Beneath the surface: a case report on nonencapsulatedAccess microbiology · 2024Article
- Pilus ofFrontiers in cellular and infection microbiology · 2023Review
- Clonal Dissemination of Plasmid-Mediated Carbapenem and Colistin Resistance in Refugees Living in Overcrowded Camps in North Lebanon.Antibiotics (Basel, Switzerland) · 2021Article
- Weaving the Strands of Life (Human biology · 2020Review
- Pneumococcal serotype determines growth and capsule size in human cerebrospinal fluid.BMC microbiology · 2020Article
- Genomic differences among carriage and invasive nontypeable pneumococci circulating in South Africa.Microbial genomics · 2019Article
- Sequencing of the variable region ofOpen biology · 2017Article
- Two cases of serotypeable and non-serotypeable variants of Streptococcus pneumoniae detected simultaneously during invasive disease.BMC microbiology · 2016Article
- Genomic analysis of nontypeable pneumococci causing invasive pneumococcal disease in South Africa, 2003-2013.BMC genomics · 2016Article
- Article
- Review
- Pneumococcal Capsules and Their Types: Past, Present, and Future.Clinical microbiology reviews · 2015Review
- Nonencapsulated Streptococcus pneumoniae causes otitis media during single-species infection and during polymicrobial infection with nontypeable Haemophilus influenzae.Pathogens and disease · 2015Article
- Mechanisms of genome evolution of Streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Non-typeable pneumococci circulating in Portugal are of cps type NCC2 and have genomic features typical of encapsulated isolates.BMC genomics · 2014Article
- Population-based analysis of invasive nontypeable pneumococci reveals that most have defective capsule synthesis genes.PloS one · 2014Article
- Impact of preceding flu-like illness on the serotype distribution of pneumococcal pneumonia.PloS one · 2014Article
- A prospective study of agents associated with acute respiratory infection among young American Indian children.The Pediatric infectious disease journal · 2013Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPneumococci could evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype capsule genes or by downregulating capsule production. We sought to assess whether pneumococci that are nontypeable (NT) by the Quellung reaction truly lack capsule genes or are failing to produce capsule in vitro.
methodsWe applied multilocus sequence typing and a microarray for detection of pneumococcal polysaccharide capsule biosynthesis genes to NT carriage (children aged <5 years; years 1997-2000, 2006-2008) and NT invasive disease (IPD) (all ages; years 1994-2007) isolates from Native American communities.
resultsTwenty-seven of 28 (96.4%) NT IPD isolates had sequence types (STs) typically found among typeable IPD isolates and contained whole or fragments of capsule genes that matched known serotypes; 1 NT-IPD isolate had a profile resembling NT carriage isolates. Forty-nine of 76 (64.5%) NT carriage isolates had STs that typically lack capsule genes and were similar to NT carriage isolates found globally.
conclusionsThis is the first documentation of IPD from an NT strain confirmed to lack all known capsule genes. Most NT IPD isolates have or had the capacity to produce capsule, whereas a majority of NT carriage isolates lack this capacity. We found no evidence of pneumococcal adaptation to PCV7 via downregulation or deletion of vaccine-serotype capsule genes.
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