ReviewProceedings. Biological sciences2012
The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin.
Review in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Sensorimotor and Molecular Mechanisms of Non-Contact ACL Injury: An Integrative Hypothesis.International journal of sports physical therapy · 2026Article
- The stretch-shortening cycle effect is not associated with cortical or spinal excitability modulations.The Journal of physiology · 2025Article
- Regulation of Poly-E Motif Flexibility by pH, CaInternational journal of molecular sciences · 2022Article
- Article
- Muscular Pre-activation Can Boost the Maximal Explosive Eccentric Adaptive Force.Frontiers in physiology · 2019Article
- Basic science and clinical use of eccentric contractions: History and uncertainties.Journal of sport and health science · 2018Review
- A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation.PLoS computational biology · 2017Article
- Oxygen consumption of gastrocnemius medialis muscle during submaximal voluntary isometric contractions with and without preceding stretch.Scientific reports · 2017Article
- The effects of a skeletal muscle titin mutation on walking in mice.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Physiological Mechanisms of Eccentric Contraction and Its Applications: A Role for the Giant Titin Protein.Frontiers in physiology · 2017Review
- Reduced activation in isometric muscle action after lengthening contractions is not accompanied by reduced performance fatigability.Scientific reports · 2016Article
- Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?Journal of muscle research and cell motility · 2016Article
- The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.American journal of physiology. Cell physiology · 2016Article
- Effects of epimuscular myofascial force transmission on sarcomere length of passive muscles in the rat hindlimb.Physiological reports · 2015Article
- The stretch-shortening cycle (SSC) revisited: residual force enhancement contributes to increased performance during fast SSCs of human m. adductor pollicis.Physiological reports · 2015Article
- Non-crossbridge forces in activated striated muscles: a titin dependent mechanism of regulation?Journal of muscle research and cell motility · 2015Review
- Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers.Cellular and molecular bioengineering · 2014Article
- Dynamic coupling of regulated binding sites and cycling myosin heads in striated muscle.The Journal of general physiology · 2014Article
- Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.Frontiers in physiology · 2014Article
- Force enhancement in lengthening contractions of cat soleus muscle in situ: transient and steady-state aspects.Physiological reports · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When activated skeletal muscles are stretched, the force increases significantly. After the stretch, the force decreases and reaches a steady-state level that is higher than the force produced at the corresponding length during purely isometric contractions. This phenomenon, referred to as residual force enhancement, has been observed for more than 50 years, but the mechanism remains elusive, generating considerable debate in the literature. This paper reviews studies performed with single muscle fibres, myofibrils and sarcomeres to investigate the mechanisms of the stretch-induced force enhancement. First, the paper summarizes the characteristics of force enhancement and early hypotheses associated with non-uniformity of sarcomere length. Then, it reviews new evidence suggesting that force enhancement can also be associated with sarcomeric structures. Finally, this paper proposes that force enhancement is caused by: (i) half-sarcomere non-uniformities that will affect the levels of passive forces and overlap between myosin and actin filaments, and (ii) a Ca(2+)-induced stiffness of titin molecules. These mechanisms are compatible with most observations in the literature, and can be tested directly with emerging technologies in the near future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.