ArticleThe Journal of general virology2012
Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States.
Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 131 citations in OpenAlex.
- Molecular and serological evidence of hepatitis E virus genotype 3 circulation in pigs in Senegal.One health (Amsterdam, Netherlands) · 2026Article
- Spillover of Rat Hepatitis E Virus into Humans: An Emerging Zoonosis?Future virology · 2025Article
- Research Progress on Hepatitis E Virus Culture.Pathogens (Basel, Switzerland) · 2025Review
- Prevalence ofJHEP reports : innovation in hepatology · 2025Article
- Cross-species transmission and histopathological variation in specific-pathogen-free minipigs infected with different hepatitis E virus strains.Veterinary research · 2024Article
- Article
- Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal.Veterinary research communications · 2024Article
- Detection of Rat Hepatitis E Virus in Pigs, Spain, 2023.Emerging infectious diseases · 2024Article
- Hepatitis E Virus in Livestock-Update on Its Epidemiology and Risk of Infection to Humans.Animals : an open access journal from MDPI · 2023Review
- Low Replication Efficiency of a Japanese Rabbit Hepatitis E Virus Strain in the Human Hepatocarcinoma Cell Line PLC/PRF/5.Viruses · 2023Article
- Serological and genetic diversity of hepatitis E virus among rabbits population in Egypt.Open veterinary journal · 2023Article
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- Article
- Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- Animal Models for Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- Article
- Research on a rat model of genotype IV swine hepatitis E virus.Veterinary medicine and science · 2022Article
- Experimental Cross-Species Transmission of Rat Hepatitis E Virus to Rhesus and Cynomolgus Monkeys.Viruses · 2022Article
- A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016.Viruses · 2021Article
- Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus.Viruses · 2021Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Hepatitis E virus (HEV) is an important human pathogen. In addition to humans, HEV has also been identified in pig, chicken, mongoose, deer, rat, rabbit and fish. There are four recognized and two putative genotypes of mammalian HEV. Genotypes 1 and 2 are restricted to humans, while genotypes 3 and 4 are zoonotic. The recently identified rabbit HEV is a distant member of genotype 3. Here, we first expressed and purified the recombinant capsid protein of rabbit HEV and showed that the capsid protein of rabbit HEV cross-reacted with antibodies raised against avian, rat, swine and human HEV. Conversely, we showed that antibodies against rabbit HEV cross-reacted with capsid proteins derived from chicken, rat, swine and human HEV. Since pigs are the natural host of genotype 3 HEV, we then determined if rabbit HEV infects pigs. Twenty pigs were divided into five groups of four each and intravenously inoculated with PBS, US rabbit HEV, Chinese rabbit HEV, US rat HEV and swine HEV, respectively. Results showed that only half of the pigs inoculated with rabbit HEV had low levels of viraemia and faecal virus shedding, indicative of active but not robust HEV infection. Infection of pigs by rabbit HEV was further verified by transmission of the virus recovered from pig faeces to naïve rabbits. Pigs inoculated with rat HEV showed no evidence of infection. Preliminary results suggest that rabbit HEV is antigenically related to other HEV strains and infects pigs and that rat HEV failed to infect pigs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.