SynthesisThe Journal of nutrition2012
Fish or long-chain (n-3) PUFA intake is not associated with pancreatic cancer risk in a meta-analysis and systematic review.
Synthesis in The Journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Diets, Dietary Patterns, Single Foods and Pancreatic Cancer Risk: An Umbrella Review of Meta-Analyses.International journal of environmental research and public health · 2022Pooled it
- Fish Consumption and the Risk of Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Meta-analysis of fish consumption and risk of pancreatic cancer in 13 prospective studies with 1.8 million participants.PloS one · 2019Pooled it
- Fish intake and ovarian cancer risk: a meta-analysis of 15 case-control and cohort studies.PloS one · 2014Pooled it
- Fish consumption and risk of esophageal cancer and its subtypes: a systematic review and meta-analysis of observational studies.European journal of clinical nutrition · 2013Pooled it
- The association between fish consumption and risk of renal cancer: a meta-analysis of observational studies.PloS one · 2013Pooled it
- Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies.Annals of translational medicine · 2023Article
- What Dietary Patterns and Nutrients are Associated with Pancreatic Cancer? Literature Review.Cancer management and research · 2023Review
- Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA.Foods (Basel, Switzerland) · 2022Review
- Dietary Intake of Fatty Acids and Risk of Pancreatic Cancer: A Case-Control Study.The Journal of nutrition · 2022Article
- Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Updated risk factors to inform early pancreatic cancer screening and identify high risk patients.Cancer letters · 2020Article
- Statins and pancreatic cancer.Oncology letters · 2017Article
- Dietary food groups intake and cooking methods associations with pancreatic cancer: a case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Fish consumption doesn't reduce the risk of hepatocellular carcinoma.International journal of clinical and experimental medicine · 2015Article
- Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study.American journal of epidemiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Long-chain (n-3) PUFA (LC-PUFA) have been hypothesized to be beneficial in preventing pancreatic carcinogenesis, but the associations of fish or LC-PUFA intake with pancreatic cancer found in epidemiologic studies have been controversial and inconclusive. To estimate the overall association of LC-PUFA or fish intake with pancreatic cancer, we performed a systematic literature search of English-language articles using PubMed and EMBASE through February 2012 and reviewed the reference lists from retrieved articles. Prospective cohort or case-control studies that reported ratio estimates and corresponding 95% CI for the associations of fish or LC-PUFA intake and pancreatic cancer were selected. Independent data extraction was performed by 2 of the authors. The pooled associations were obtained by using a random-effects model. A database was derived from 9 independent cohorts that included 1,209,265 participants (3082 events) with a mean follow-up of 9 y and 10 independent case-control studies that included 2514 cases and 18,779 controls. Compared with those having the lowest fish consumption, the pooled RR of pancreatic cancer was 0.98 (95% CI: 0.86, 1.12) for those who had the highest fish intake from 8 cohort studies and was 0.96 (95% CI: 0.76, 1.21) from 9 case-control studies. We found similar results for LC-PUFA intake by combining data from 4 cohorts or 2 case-control studies. Our results do not support an overall inverse association of fish or LC-PUFA intake with risk of pancreatic cancer. Further studies that consider different species and preparation methods of fish, and additional adjustment for contaminants in fish, are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.