ArticleInternational journal of clinical pharmacy2012
Evaluation of drug-drug interaction screening software combined with pharmacist intervention.
Article in International journal of clinical pharmacy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Drug-drug interaction among elderly patients in Africa: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2025Pooled it
- Information Technology-Based Interventions to Improve Drug-Drug Interaction Outcomes: A Systematic Review on Features and Effects.Journal of medical systems · 2017Pooled it
- Interactions Between Direct Oral Anticoagulants and Drugs Involving CYP-Enzymes and P-gp Transporters Detected by a Clinical Decision Support System: A Retrospective Cohort Study.Cardiovascular drugs and therapy · 2026Article
- The comorbidity and co-medication profile of patients with progressive supranuclear palsy.Journal of neurology · 2024Article
- Experiences and Outcomes of Using e-Prescribing for Opioids: Rapid Scoping Review.Journal of medical Internet research · 2023Article
- Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients.Infectious diseases and therapy · 2023Article
- Article
- Factors associated with a basic common drug-drug interaction knowledge among emergency department medical personnel.BMC pharmacology & toxicology · 2022Article
- Potential drug-drug interactions in patients with cardiovascular diseases: findings from a prospective observational study.Journal of pharmaceutical policy and practice · 2021Article
- Drug safety profiles in geriatric patients with Parkinson's disease using the FORTA (Fit fOR The Aged) classification: results from a mono-centric retrospective analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Potential drug-drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria.Malaria journal · 2020Article
- Interventions to reduce medication errors in adult medical and surgical settings: a systematic review.Therapeutic advances in drug safety · 2020Review
- Drug-drug interactions and pharmacists' interventions among psychiatric patients in outpatient clinics of a teaching hospital in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?BMC pharmacology & toxicology · 2019Article
- Safety and Tolerability of Pharmacotherapies for Parkinson's Disease in Geriatric Patients.Drugs & aging · 2019Review
- Potential Drug-Drug Interactions in Patients With Urinary Tract Infections: A Contributing Factor in Patient and Medication Safety.Frontiers in pharmacology · 2019Article
- Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.Medicine · 2016Observational
- Drug-drug interactions and acute kidney injury: caveat prescriptor.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Article
- Article
- Detection of potential drug-drug interactions for outpatients across hospitals.International journal of environmental research and public health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug-drug interactions (DDI) in hospitalized patients are highly prevalent and an important source of adverse drug reactions. DI computerized screening system can prevent the occurrence of some of these events.
objectiveTo evaluate the impact of drug-drug interaction (DDI) screening software combined with active intervention in preventing drug interactions.
settingThe study was conducted at General Hospital of Vitória da Conquista (HGVC), Brazil.
methodA quasi-experimental study was used to evaluate the impact of IM-Pharma, a locally developed drug-drug interaction screening system, coupled with pharmacist intervention on adverse drug events in the hospital setting.
main outcome measureThe proportion of patients co-prescribed two interacting drugs were measured in two phases, prior the implementation of IM-Pharma and during the intervention period. DDI rates per 100 patient days were calculated before and after implementation. Risk ratios were estimated by Poisson regression models.
resultsA total of 6,834 instances of drug-drug interactions were identified; there was an average of 3.3 DDIs per patient in phase one and 2.5 in phase two, a reduction of 24 % (P = 0.03). There was a 71 % reduction in high-severity drug-drug interaction (P < 0.01). The risk for all DDIs decreased 50 % after the implementation of IM-Pharma (P < 0.01), and for those with high-severity, the reduction was 81 % (P < 0.01).
conclusionThe performance of IM-Pharma combined with pharmacist intervention was positive with an expressive reduction in the risk of DDIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.