ArticleCellular oncology (Dordrecht, Netherlands)2012
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer.
Article in Cellular oncology (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Prognostic role of HSPs in human colorectal cancer: a systematic review and meta-analysis.BMC cancer · 2026Pooled it
- Prognostic and clinicopathological significance of heat shock proteins in colorectal cancer patients: a meta-analysis.World journal of surgical oncology · 2026Pooled it
- The Prognostic Significance of Hsp70 in Patients with Colorectal Cancer Patients: A PRISMA-Compliant Meta-Analysis.BioMed research international · 2021Pooled it
- Exogenous Heat Shock Proteins in Oncology: Biological Roles and Clinical Implications.Cancers · 2026Review
- Immunohistochemical TTF-1 and Napsin a Expression in Gastrointestinal Adenocarcinomas-Low Frequency but an Important Pitfall.Diagnostics (Basel, Switzerland) · 2025Article
- Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity.BMC genomics · 2024Article
- Article
- Exploring pathological signatures for predicting the recurrence of early-stage hepatocellular carcinoma based on deep learning.Frontiers in oncology · 2022Article
- Article
- p16 is superior to Stathmin-1 and HSP27 in identifying cervical dysplasia.Diagnostic pathology · 2021Article
- Heat Shock Proteins 27, 70, and 110: Expression and Prognostic Significance in Colorectal Cancer.Cancers · 2021Article
- Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions.BioMed research international · 2021Article
- Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B.Advanced pharmaceutical bulletin · 2020Article
- Heat shock proteins in cancer stem cell maintenance: A potential therapeutic target?Histology and histopathology · 2020Review
- Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma.World journal of clinical cases · 2019Article
- Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma.PloS one · 2019Article
- LY2228820 induces synergistic anti-cancer effects with anti-microtubule chemotherapeutic agents independent of P-glycoprotein in multidrug resistant cancer cells.American journal of cancer research · 2019Article
- Article
- A comparison of cell survival and heat shock protein expression after radiation in normal dermal fibroblasts, microvascular endothelial cells, and different head and neck squamous carcinoma cell lines.Clinical oral investigations · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer. MATERIAL AND
methodsHSP expression was determined by immunohistochemistry on a tissue microarray with 355 primary resected colon carcinomas of all stages. Expression patterns were correlated with pathologic features (UICC pTNM category, tumor grading) and survival.
resultsExpression of HSP27, HSP60 and HSP70 ranged from negative to high. There was no correlation between HSP27, HSP60 and HSP70 expression among each other and with UICC pT category, presence of lymph node or distant metastases or tumor grading. High HSP70 expression was associated with worse overall survival (p < 0.001) and was an independent prognostic factor (p = 0.004) in multivariate analysis including the pathological parameters mentioned above. For patients without lymph node or distant metastases (UICC stages I/II) and with complete tumor excision, HSP70 expression was the only independent prognostic factor for survival (p = 0.001) and superior to UICC pT category. In left sided UICC stage I/II carcinomas, high HSP27 expression also had adverse prognostic impact and was an independent prognostic factor (p = 0.016) besides HSP70 (p = 0.002).
conclusionHigh HSP70 and HSP27 expression is associated with worse clinical outcome in colon cancer. Determination of tumoral HSP70 and HSP27 may be used as additional biomarker for risk stratification especially for UICC stage I/II patients.
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