ArticlePlant physiology2012
DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 105 citations in OpenAlex.
- Physiological-Biochemical Characteristics and Omics Landscape of Drought Tolerance inInternational journal of molecular sciences · 2026Article
- Molecular regulation of plant endoreduplication: core mechanisms and their upstream control.Plant molecular biology · 2026Review
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- Article
- Type-B response regulator OsRR22 forms a transcriptional activation complex with OsSLR1 to modulate OsHKT2;1 expression in rice.Science China. Life sciences · 2023Article
- Past accomplishments and future challenges of the multi-omics characterization of leaf growth.Plant physiology · 2022Review
- Genome-wide analysis and functional characterization of the DELLA gene family associated with stress tolerance in B. napus.BMC plant biology · 2021Article
- MYB3R-mediated active repression of cell cycle and growth under salt stress in Arabidopsis thaliana.Journal of plant research · 2021Article
- Understanding the Role of Gibberellic Acid and Paclobutrazol in Terminal Heat Stress Tolerance in Wheat.Frontiers in plant science · 2021Article
- The role of salicylic acid and gibberellin signaling in plant responses to abiotic stress with an emphasis on heavy metals.Plant signaling & behavior · 2020Article
- SLENDER RICE1 andPlant physiology · 2020Article
- How grass keeps growing: an integrated analysis of hormonal crosstalk in the maize leaf growth zone.The New phytologist · 2020Article
- Transcriptomic Study for Identification of Major Nitrogen Stress Responsive Genes in Australian Bread Wheat Cultivars.Frontiers in genetics · 2020Article
- Apoplastic Hydrogen Peroxide in the Growth Zone of the Maize Primary Root. Increased Levels Differentially Modulate Root Elongation Under Well-Watered and Water-Stressed Conditions.Frontiers in plant science · 2020Article
- AP2/ERF Transcription Factor Regulatory Networks in Hormone and Abiotic Stress Responses inFrontiers in plant science · 2019Review
- Early mannitol-triggered changes in the Arabidopsis leaf (phospho)proteome reveal growth regulators.Journal of experimental botany · 2018Article
- Article
- Rice tocopherol deficiency 1 encodes a homogentisate phytyltransferase essential for tocopherol biosynthesis and plant development in rice.Plant cell reports · 2018Article
- Abscisic Acid and Gibberellins Antagonistically Mediate Plant Development and Abiotic Stress Responses.Frontiers in plant science · 2018Review
- From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress.Molecular systems biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have developed unique mechanisms to respond to stress. Previously, we studied the effects of osmotic stress on dividing leaf cells in Arabidopsis (Arabidopsis thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division and start endoreduplication earlier. In this study, we analyzed this phenomenon in more detail. Osmotic stress induces changes in gibberellin metabolism, resulting in the stabilization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication. Consequently, this response is absent in mutants with altered gibberellin levels or DELLA activity. Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation.
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