ArticleNeurocritical care2013
Regional brain injury on conventional and diffusion weighted MRI is associated with outcome after pediatric cardiac arrest.
Article in Neurocritical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 8. Pediatric advanced life support.Clinical and experimental emergency medicine · 2026Guideline
- Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest.Resuscitation · 2025Trial
- Brain MR imaging and spectroscopy for outcome prognostication after pediatric cardiac arrest.Resuscitation · 2020Trial
- Continuation or Withdrawal of Life-sustaining Therapies After Acute Anoxic Events in Childhood and Adolescence : Can Early MRI Predict Particularly Severe Outcomes?Clinical neuroradiology · 2026Article
- Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest.Resuscitation · 2026Article
- Neuroprotection provided by hypothermia initiated with high transnasal flow with ambient air in a model of pediatric cardiac arrest.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- The impact of pediatric post-cardiac arrest care on survival: A multicenter review from the AHA get with the Guidelines®-resuscitation post-cardiac arrest care registry.Resuscitation · 2024Article
- Long-term multidisciplinary follow-up programs in pediatric cardiac arrest survivors.Resuscitation plus · 2024Article
- Review
- Assessment of Brain Magnetic Resonance and Spectroscopy Imaging Findings and Outcomes After Pediatric Cardiac Arrest.JAMA network open · 2023Article
- Limbic pathway vulnerability associates with neurologic outcome in children after cardiac arrest.Resuscitation · 2023Article
- Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices.Pediatric neurology · 2022Article
- Magnetic resonance imaging adds prognostic value to EEG after pediatric cardiac arrest.Resuscitation · 2022Observational
- Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome.Resuscitation · 2022Article
- Association of MRI Brain Injury With Outcome After Pediatric Out-of-Hospital Cardiac Arrest.Neurology · 2021Article
- Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study.BMJ open · 2020Article
- Neurological Prognostication in Children After Cardiac Arrest.Pediatric neurology · 2020Review
- Global and Regional Derangements of Cerebral Blood Flow and Diffusion Magnetic Resonance Imaging after Pediatric Cardiac Arrest.The Journal of pediatrics · 2016Observational
- Bilateral symmetrical basal ganglia and thalamic lesions in children: an update (2015).Neuroradiology · 2015Review
- Early diffusion-weighted magnetic resonance imaging in children after cardiac arrest may provide valuable prognostic information on clinical outcome.Intensive care medicine · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTo assess regional brain injury on magnetic resonance imaging (MRI) after pediatric cardiac arrest (CA) and to associate regional injury with patient outcome and effects of hypothermia therapy for neuroprotection.
methodsWe performed a retrospective chart review with prospective imaging analysis. Children between 1 week and 17 years of age who had a brain MRI in the first 2 weeks after CA without other acute brain injury between 2002 and 2008 were included. Brain MRI (1.5 T General Electric, Milwaukee, WI, USA) images were analyzed by 2 blinded neuroradiologists with adjudication; images were visually graded. Brain lobes, basal ganglia, thalamus, brain stem, and cerebellum were analyzed using T1, T2, and diffusion-weighted images (DWI).
resultsWe examined 28 subjects with median age 1.9 years (IQR 0.4-13.0) and 19 (68 %) males. Increased intensity on T2 in the basal ganglia and restricted diffusion in the brain lobes were associated with unfavorable outcome (all P < 0.05). Therapeutic hypothermia had no effect on regional brain injury. Repeat brain MRI was infrequently performed but demonstrated evolution of lesions.
conclusionChildren with lesions in the basal ganglia on conventional MRI and brain lobes on DWI within the first 2 weeks after CA represent a group with increased risk of poor outcome. These findings may be important for developing neuroprotective strategies based on regional brain injury and for evaluating response to therapy in interventional clinical trials.
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