ArticleThe American journal of psychiatry2012
Differing amygdala responses to facial expressions in children and adults with bipolar disorder.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Developmental meta-analyses of the functional neural correlates of bipolar disorder.JAMA psychiatry · 2014Pooled it
- An Open Pilot Study of Training Hostile Interpretation Bias to Treat Disruptive Mood Dysregulation Disorder.Journal of child and adolescent psychopharmacology · 2016Trial
- Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- Microsaccadic modulation evoked by emotional events.Journal of physiological anthropology · 2020Review
- Neural processing of infant and adult face emotion and maternal exposure to childhood maltreatment.Social cognitive and affective neuroscience · 2019Article
- Neural mechanisms of face emotion processing in youths and adults with bipolar disorder.Bipolar disorders · 2019Article
- Telomere length as a predictor of emotional processing in the brain.Human brain mapping · 2019Article
- Reliability of neural activation and connectivity during implicit face emotion processing in youth.Developmental cognitive neuroscience · 2018Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology.JAMA psychiatry · 2017Article
- Dysfunctional gaze processing in bipolar disorder.NeuroImage. Clinical · 2017Article
- Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Article
- Facial emotion recognition in childhood-onset bipolar I disorder: an evaluation of developmental differences between youths and adults.Bipolar disorders · 2015Article
- Widespread white matter tract aberrations in youth with familial risk for bipolar disorder.Psychiatry research · 2015Article
- Neural response during explicit and implicit face processing varies developmentally in bipolar disorder.Social cognitive and affective neuroscience · 2014Article
- Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: attenuated by medication.Journal of psychiatric research · 2014Article
- A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.The American journal of psychiatry · 2014Review
- Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands.Psychological medicine · 2014Article
- Meta-analyses of developing brain function in high-risk and emerged bipolar disorder.Frontiers in psychiatry · 2014Article
- A systems neuroscience approach to the pathophysiology of pediatric mood and anxiety disorders.Current topics in behavioral neurosciences · 2014Review
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Abstract
objectiveChild and adult bipolar patients show both behavioral deficits in face emotion processing and abnormal amygdala activation. However, amygdala function in pediatric relative to adult bipolar patients has not been compared directly. The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects.
methodAmygdala responses to emotional facial expressions were examined in pediatric (N=18) and adult (N=17) bipolar patients and in healthy child (N=15) and adult (N=22) volunteers. Participants performed a gender identification task while viewing fearful, angry, and neutral faces.
resultsIn response to fearful faces, bipolar patients across age groups exhibited right amygdala hyperactivity relative to healthy volunteers. However, when responses to all facial expressions were combined, pediatric patients exhibited greater right amygdala activation than bipolar adults and healthy children.
conclusionsAmygdala hyperactivity in response to fearful faces is present in both youths and adults with bipolar disorder. However, compared with bipolar adults and healthy child volunteers, pediatric bipolar patients showed amygdala hyperactivity in response to a broad array of emotional faces. Thus, abnormal amygdala activation during face processing appears to be more pervasive in children than in adults with bipolar disorder. Longitudinal studies are needed to elucidate the mechanisms of this developmental difference, thus facilitating developmentally sensitive diagnosis and treatment.
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