ArticleThe American journal of psychiatry2012
Maternal antibodies to dietary antigens and risk for nonaffective psychosis in offspring.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- The Differences between Gluten Sensitivity, Intestinal Biomarkers and Immune Biomarkers in Patients with First-Episode and Chronic Schizophrenia.Journal of clinical medicine · 2020Article
- Deciphering microbiome and neuroactive immune gene interactions in schizophrenia.Neurobiology of disease · 2020Review
- Autoimmune phenotypes in schizophrenia reveal novel treatment targets.Pharmacology & therapeutics · 2018Review
- Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.Brain, behavior, and immunity · 2017Article
- Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.Psychosomatic medicine · 2016Article
- Role of Immune and Autoimmune Dysfunction in Schizophrenia.Handbook of behavioral neuroscience · 2016Article
- The aetiology of schizophrenia: what have the Swedish Medical Registers taught us?Social psychiatry and psychiatric epidemiology · 2015Review
- Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.Schizophrenia research · 2014Article
- Maternal complement C1q and increased odds for psychosis in adult offspring.Schizophrenia research · 2014Article
- Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder.Bipolar disorders · 2014Article
- Inflammation and the two-hit hypothesis of schizophrenia.Neuroscience and biobehavioral reviews · 2014Review
- Neonatal levels of acute phase proteins and later risk of non-affective psychosis.Translational psychiatry · 2013Article
- Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia.Neurobiology of disease · 2012Article
- The last therapeutic orphan: the pregnant woman.The American journal of psychiatry · 2012Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe authors analyzed archival dried blood spots obtained from newborns to assess whether levels of immunoglobulin G (IgG) directed at dietary antigens were associated with a later diagnosis of a nonaffective psychotic disorder.
methodThe study population consisted of individuals born in Sweden between 1975 and 1985 with verified register-based diagnoses of nonaffective psychoses made between 1987 and 2003 and comparison subjects matched on sex, date of birth, birth hospital, and municipality. A total of 211 case subjects and 553 comparison subjects consented to participate in the study. Data on factors associated with maternal status, pregnancy, and delivery were extracted from the Swedish Medical Birth Register. Levels of IgG directed at gliadin (a component of gluten) and casein (a milk protein) were analyzed in eluates from dried blood spots by enzyme-linked immunosorbent assay. Odds ratios were calculated for levels of IgG directed at gliadin or casein for nonaffective psychosis.
resultsLevels of anti-gliadin IgG (but not anti-casein IgG) above the 90th percentile of levels observed among comparison subjects were associated with nonaffective psychosis (odds ratio=1.7, 95% CI=1.1-2.8). This association was not confounded by differences in maternal age, immigrant status, or mode of delivery. Similarly, gestational age at birth, ponderal index, and birth weight were not related to maternal levels of anti-gliadin IgG.
conclusionsHigh levels of anti-gliadin IgG in the maternal circulation are associated with an elevated risk for the development of a nonaffective psychosis in offspring. Research is needed to identify the mechanisms underlying this association in order to develop preventive strategies.
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