ArticleEuropean journal of human genetics : EJHG2012
Mini-haplotypes as lineage informative SNPs and ancestry inference SNPs.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Portable Microhaplotype Object and Tools.bioRxiv : the preprint server for biology · 2025Article
- Estimation of genetic admixture proportions via haplotypes.Computational and structural biotechnology journal · 2024Article
- Solution to a case involving the interpretation of trace degraded DNA mixtures.International journal of legal medicine · 2024Article
- Forensic biogeographical ancestry inference: recent insights and current trends.Genes & genomics · 2023Review
- North Asian population relationships in a global context.Scientific reports · 2022Article
- Research progress on application of microhaplotype in forensic genetics.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Review
- Massive parallel sequencing in forensics: advantages, issues, technicalities, and prospects.International journal of legal medicine · 2020Review
- Construction and forensic application of 20 highly polymorphic microhaplotypes.Royal Society open science · 2020Article
- Identifying novel microhaplotypes for ancestry inference.International journal of legal medicine · 2019Article
- Inferring biogeographic ancestry with compound markers of slow and fast evolving polymorphisms.European journal of human genetics : EJHG · 2018Article
- Separation/extraction, detection, and interpretation of DNA mixtures in forensic science (review).International journal of legal medicine · 2018Review
- Multi-InDel Analysis for Ancestry Inference of Sub-Populations in China.Scientific reports · 2016Article
- Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome.Scientific reports · 2016Article
- Criteria for selecting microhaplotypes: mixture detection and deconvolution.Investigative genetics · 2015Article
- Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases.Cell cycle (Georgetown, Tex.) · 2014Article
- DNA fingerprinting in forensics: past, present, future.Investigative genetics · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
We propose that haplotyped loci with high heterozygosity can be useful in human identification, especially within families, if recombination is very low among the sites. Three or more SNPs extending over small molecular intervals (<10 KB) can be identified in the human genome to define miniature haplotypes with moderate levels of linkage disequilibrium. Properly selected, these mini-haplotypes (or minihaps) consist of multiple haplotype lineages (alleles) that have evolved from the ancestral human haplotype but show no evidence of recurring recombination, allowing each distinct haplotype to be equated with an allele, all copies of which are essentially identical by descent. Historic recombinants, representing rare events that have drifted to common frequencies over many generations, can be identified in some cases, they do not equate to frequently recurring recombination. We have identified examples in our data collected on various projects and present eight such mini-haplotypes comprised of informative SNPs. We also discuss the ideal characteristics and advantages of minihaps for human familial identification and ancestry inference, and compare them to other types of forensic markers in use and/or that have been proposed. We expect that it is possible to carry out a systematic search and identify a useful panel of mini-haplotypes, with even better properties than the examples presented here.
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