ArticleCancer causes & control : CCC2012
A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women.
Article in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Difference in Gastrointestinal Cancer Risk and Mortality by Dietary Pattern Analysis: A Systematic Review and Meta-Analysis.Nutrition reviews · 2025Pooled it
- Sex consideration in diet-biomarker-related indices: a systematic review.Public health nutrition · 2018Pooled it
- Association of dietary patterns derived by reduced-rank regression with colorectal cancer risk and mortality.European journal of nutrition · 2024Trial
- Low carbohydrate intake correlates with trends of insulin resistance and metabolic acidosis in healthy lean individuals.Frontiers in public health · 2023Observational
- Serum C-peptide level and the risk of cardiovascular diseases mortality and all-cause mortality: a meta-analysis and systematic review.Frontiers in cardiovascular medicine · 2023Review
- Insulinemic potential of diet and risk of total and subtypes of breast cancer among US females.The American journal of clinical nutrition · 2022Article
- Development and validation of dietary and lifestyle insulinemic indices among Iranian adult population.Nutrition & metabolism · 2022Article
- Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases.Frontiers in oncology · 2022Review
- The relationship between dietary patterns, dietary quality index, and dietary inflammatory index with the risk of all types of cancer: Golestan cohort study.Medical journal of the Islamic Republic of Iran · 2021Article
- Review
- Dietary patterns and cancer risk.Nature reviews. Cancer · 2020Review
- Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.Nature reviews. Gastroenterology & hepatology · 2019Review
- Dietary Patterns Related to Triglyceride and High-Density Lipoprotein Cholesterol and the Incidence of Type 2 Diabetes in Korean Men and Women.Nutrients · 2018Article
- The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro.Molecules (Basel, Switzerland) · 2018Review
- Association of the Insulinemic Potential of Diet and Lifestyle With Risk of Digestive System Cancers in Men and Women.JNCI cancer spectrum · 2018Article
- Association of dietary insulinemic potential and colorectal cancer risk in men and women.The American journal of clinical nutrition · 2018Article
- Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Observational
- Dietary Patterns and Colorectal Cancer Risk: A Review of 17 Years of Evidence (2000-2016).Current colorectal cancer reports · 2017Article
- Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results From CALGB 89803 (Alliance).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Observational
- A DASH dietary pattern and the risk of colorectal cancer in Canadian adults.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2015Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeHigher serum C-peptide concentrations have shown to be associated with an increased risk of colorectal cancer (CRC). Therefore, we used diet information to identify food groups that correlated with fasting serum concentrations of C-peptide and assess the association of this dietary pattern and CRC risk.
methodsMajor food contributors to fasting C-peptide concentrations were identified with stepwise linear regression in a subsample (n = 833) of women from a large cohort. We then summed the consumption frequency of the major food contributors to form a C-peptide dietary pattern for the entire cohort (n = 66,714). Risk for CRC was computed using Cox proportional hazard model with the C-peptide dietary pattern score as the predictor.
resultsIn up to 20 years of follow-up, we ascertained 985 cases of CRC and 758 colon cancer. After adjusting for confounders, the C-peptide dietary pattern, characterized by higher meat, fish, and sweetened beverage intake, but lower coffee, high fat dairy, and whole grains intake, showed direct association with CRC risk (RR comparing extreme quintiles = 1.29, 95 % CI = 1.05-1.58, p trend = 0.048). The same comparison was slightly stronger for colon cancer (RR = 1.35, 95 % CI = 1.07-1.70, p trend = 0.009). In stratified analysis, there was no association between the C-peptide dietary pattern and colon cancer among lean and active women. However, for overweight or sedentary women, RR for the same comparison was 1.58 (95 % CI = 1.20-2.07, p trend = 0.002) (p for interaction = 0.007).
conclusionWe derived a dietary pattern that correlated with C-peptide concentrations. This pattern was associated with an increase in colon cancer, especially among women who were overweight or sedentary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.