ArticleKidney international2012
Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Improving outcomes in kidney transplantation through advances in donor organ perfusion.Nature reviews. Nephrology · 2025Review
- Mitochondrial responses to brain death in solid organ transplant.Frontiers in transplantation · 2023Review
- Supplemental nitrite increases choroidal neovascularization in mice.Nitric oxide : biology and chemistry · 2021Article
- Minimizing Ischemia Reperfusion Injury in Xenotransplantation.Frontiers in immunology · 2021Review
- Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.Journal of nephrology · 2019Review
- Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives.Scientific reports · 2019Article
- Delayed graft function and its management in children.Pediatric nephrology (Berlin, Germany) · 2017Review
- Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings.Scientific reports · 2017Article
- Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment.World journal of transplantation · 2015Review
- Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine.Critical care (London, England) · 2015Article
- Mechanisms of nitrite bioactivation.Nitric oxide : biology and chemistry · 2014Review
- Inorganic nitrite supplementation for healthy arterial aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Redox therapeutics in hepatic ischemia reperfusion injury.World journal of hepatology · 2014Review
- Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype.Circulation research · 2012Article
- Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality.Free radical biology & medicine · 2012Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
Renal injury induced by brain death is characterized by ischemia and inflammation, and limiting it is a therapeutic goal that could improve outcomes in kidney transplantation. Brain death resulted in decreased circulating nitrite levels and increased infiltrating inflammatory cell infiltration into the kidney. Since nitrite stimulates nitric oxide signaling in ischemic tissues, we tested whether nitrite therapy was beneficial in a rat model of brain death followed by kidney transplantation. Nitrite, administered over 2 h of brain death, blunted the increased inflammation without affecting brain death-induced alterations in hemodynamics. Kidneys were transplanted after 2 h of brain death and renal function followed over 7 days. Allografts collected from nitrite-treated brain-dead rats showed significant improvement in function over the first 2 to 4 days after transplantation compared with untreated brain-dead animals. Gene microarray analysis after 2 h of brain death without or with nitrite therapy showed that the latter significantly altered the expression of about 400 genes. Ingenuity Pathway Analysis indicated that multiple signaling pathways were affected by nitrite, including those related to hypoxia, transcription, and genes related to humoral immune responses. Thus, nitrite therapy attenuates brain death-induced renal injury by regulating responses to ischemia and inflammation, ultimately leading to better post-transplant kidney function.
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Registered trials
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