Evidence map›Paper›PMID 22534708›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2012

The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes.

Nikolaos P E Kadoglou, Ioannis S Vrabas, Alkistis Kapelouzou, Stilianos Lampropoulos, Nikolaos Sailer, Alkiviadis Kostakis, Christos D Liapis, Nikoletta Angelopoulou

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Systematic Review: Does Exercise Training Influence Ghrelin Levels?International journal of molecular sciences · 2025
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  13. Resistance circuit training reduced inflammatory cytokines in a cohort of male adults with Down syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2013
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  20. Exerkines and myokines in aging sarcopenia.Frontiers in endocrinology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Nikolaos P E KadoglouDepartment of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Thessaloniki, Greece. nikoskad@yahoo.com
Ioannis S Vrabas
Alkistis Kapelouzou
Stilianos Lampropoulos
Nikolaos Sailer
Alkiviadis Kostakis
Christos D Liapis
Nikoletta Angelopoulou
Aristotle University of Thessaloniki · GRAcademy of Athens · GRIppokrateio General Hospital of Thessaloniki · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating data support the atheroprotective role of the novel adipokines, apelin and ghrelin. The aim of the present randomized study was to investigate the effects of aerobic exercise training on these adipokines in patients with type 2 diabetes mellitus (T2DM). MATERIAL/

methodsFifty-four overweight (BMI >25 kg/m²) patients with T2DM, but without vascular complications, were randomized to either the aerobic exercise training group (EG, N=27), 4 times/week, 45-60 min/session; or to the control group (CG, N=27), orally instructed to increase physical activity. Clinical glycemic and lipid parameters, exercise capacity (VO₂peak), insulin, HOMA-IR, and serum levels of apelin and ghrelin were assessed at baseline and after 12 weeks.

resultsAerobic exercise significantly improved lipid and glycemic profile and insulin sensitivity compared to CG (p<0.05). Furthermore, between-groups comparison showed a considerable exercise-induced upregulation in apelin (p=0.007) and VO₂peak (p<0.001) levels. Negligible changes in body-weight, waist-hip ratio and ghrelin concentrations were detected within and between groups after the completion of the study (p>0.05). However, subgroup analysis revealed a considerable increment in ghrelin levels only in the exercise-treated women compared to their control counterparts (p=0.038). LDL and HOMA-IR reduction were found to be independent predictors of apelin increment in multiple regression analysis (R²=0.391, p=0.011).

conclusionsIn patients with T2DM, systemic, long-term, aerobic exercise exerts positive effects on apelin and ghrelin (only in women), even in the absence of significant weight loss, suggesting its pleiotropic effects.

Indexed as

ExerciseApelinDiabetes Mellitus, Type 2FemaleGhrelinHumansIntercellular Signaling Peptides and ProteinsMaleMiddle AgedApelinAPLN protein, humanGhrelinIntercellular Signaling Peptides and Proteins

Identifiers

PMID22534708
PMCPMC3560628
OpenAlexW1970860759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.