ArticleBrain research2012
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Article in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Deletion of the P/Q-Type Calcium Channel from Serotonergic Neurons Drives Male Aggression in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spatiotemporal patterns of gene expression around implanted silicon electrode arrays.Journal of neural engineering · 2021Article
- Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.Brain communications · 2021Article
- Serotonergic modulation across sensory modalities.Journal of neurophysiology · 2020Review
- Article
- Specific Connectivity and Unique Molecular Identity of MET Receptor Tyrosine Kinase Expressing Serotonergic Neurons in the Caudal Dorsal Raphe Nuclei.ACS chemical neuroscience · 2017Article
- Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain.Scientific reports · 2016Article
- The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.PloS one · 2015Article
- A group of non-serotonergic cells is CO2-stimulated in the medullary raphé.Neuroscience · 2014Article
- Serotonergic neuron regulation informed by in vivo single-cell transcriptomics.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Functional associations among G protein-coupled neurotransmitter receptors in the human brain.BMC neuroscience · 2014Article
- Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy.Frontiers in neural circuits · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The dorsal raphe nucleus (DR) is the major source of serotonin (5-hydroxytryptamine, 5-HT) in the forebrain and dysfunction of this midbrain structure is implicated in affective disorders. The DR is composed of several types of 5-HT and non-5-HT neurons and their excitable-membrane properties are heterogeneous and overlapping. In order to understand how these properties may be generated, we examined the mRNA expression patterns of voltage- and ligand-gated ion channels in the DR using the Allen Mouse Brain Atlas. Since DR cytoarchitecture is organized with respect to the midline, we sought to identify genes that were expressed in a pattern with respect to the midline, either enriched or depleted, rather than those that were homogenously expressed throughout the DR. Less than 10% of the screened genes for voltage-gated ion channels showed patterned expression within the DR. Identified genes included voltage-gated sodium channel beta subunits, potassium channels, P/Q-, N-type calcium channels, as well as the alpha2/delta-1 calcium channel. Several voltage-gated chloride channels were also identified, although these may function within intracellular compartments. Of the ligand-gated ion channels examined, 20% showed patterned expression. These consisted primarily of glutamate and GABA-A receptor subunits. The identified genes likely contribute to unique excitable properties of different groups of neurons in the DR and may include novel pharmacologic targets for affective disorders.
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