ArticleReproductive sciences (Thousand Oaks, Calif.)2012
Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Prediabetes, diabetes, and folate status among United States women of reproductive age: NHANES 2011-March 2020.The American journal of clinical nutrition · 2026Article
- Exploring Research Trends and Mechanisms: Maternal Diabetes and Neural Tube Defects (1991-2023).Journal of multidisciplinary healthcare · 2025Article
- Ectopic Lipid Accumulation Correlates with Cellular Stress in Rabbit Blastocysts from Diabetic Mothers.International journal of molecular sciences · 2023Article
- Disturbed intracellular calcium homeostasis in neural tube defects in diabetic embryopathy.Biochemical and biophysical research communications · 2019Article
- Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.American journal of obstetrics and gynecology · 2018Article
- Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy.Scientific reports · 2017Article
- Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Reevaluation of Antioxidative Strategies for Birth Defect Prevention in Diabetic Pregnancies.Journal of biomolecular research & therapeutics · 2016Article
- The status of diabetic embryopathy.Upsala journal of medical sciences · 2016Review
- Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin.Scientific reports · 2016Article
- Identification of novel cell survival regulation in diabetic embryopathy via phospholipidomic profiling.Biochemical and biophysical research communications · 2016Article
- Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity.International review of cell and molecular biology · 2015Review
- Vinyl chloride monomer (VCM) induces high occurrence of neural tube defects in embryonic mouse brain during neurulation.Cellular and molecular neurobiology · 2014Article
- New concepts in diabetic embryopathy.Clinics in laboratory medicine · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Maternal diabetes-induced neural tube defects (NTDs) are associated with increased programmed cell death (apoptosis) in the neuroepithelium, which is related to intracellular nitrosative stress. To alleviate nitrosative stress, diabetic pregnant mice were fed via gavage an inhibitor of nitric oxide (NO) synthase (NOS) 2, L-N6-(1-iminoethyl)-lysine (L-NIL; 80 mg/kg), once a day from embryonic (E) day 7.5 to 9.5 during early stages of neurulation. The treatment significantly reduced NTD rate in the embryos, compared with that in vehicle (normal saline)-treated diabetic group. In addition to alleviation of nitrosative stress, endoplasmic reticulum (ER) stress was also ameliorated, assessed by quantification of associated factors. Apoptosis was reduced, indicated by caspase 8 activation. These results show that nitrosative stress is important in diabetes-induced NTDs via exacerbating ER stress, leading to increased apoptosis. Oral treatment with NOS-2 inhibitor alleviates nitrosative and ER stress, decreases apoptosis, and reduces NTDs in the embryos, providing information for further interventional studies to reduce diabetes-associated birth defects.
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