ArticleGenome biology and evolution2012
Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Characterization of antibiotic resistance and biofilm formation in clinical Helicobacter pylori isolates from Ningxia, China.Scientific reports · 2025Article
- Review
- Homologous recombination shapes the architecture and evolution of bacterial genomes.Nucleic acids research · 2025Article
- Homologous Recombination Shapes the Architecture and Evolution of Bacterial Genomes.bioRxiv : the preprint server for biology · 2024Article
- Review
- Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.Communications biology · 2023Article
- RecombinantAntibiotics (Basel, Switzerland) · 2022Review
- Article
- Outer Membrane Vesicles Secreted byACS omega · 2022Article
- Recombination-independent rapid convergent evolution of the gastric pathogen Helicobacter pylori.BMC genomics · 2018Article
- Investigation of recombination-intense viral groups and their genes in the Earth's virome.Scientific reports · 2018Article
- Genomic divergence and cohesion in a species of pelagic freshwater bacteria.BMC genomics · 2017Article
- Review
- Diversification of the AlpB Outer Membrane Protein of Helicobacter pylori Affects Biofilm Formation and Cellular Adhesion.Journal of bacteriology · 2017Article
- Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins.Scientific reports · 2017Article
- Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua.BMC evolutionary biology · 2016Article
- Comparative Analysis of TwoFrontiers in microbiology · 2016Article
- A Novel Approach to Helicobacter pylori Pan-Genome Analysis for Identification of Genomic Islands.PloS one · 2016Article
- Transmission of the PabI family of restriction DNA glycosylase genes: mobility and long-term inheritance.BMC genomics · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature of a species remains a fundamental and controversial question. The era of genome/metagenome sequencing has intensified the debate in prokaryotes because of extensive horizontal gene transfer. In this study, we conducted a genome-wide survey of outcrossing homologous recombination in the highly sexual bacterial species Helicobacter pylori. We conducted multiple genome alignment and analyzed the entire data set of one-to-one orthologous genes for its global strains. We detected mosaic structures due to repeated recombination events and discordant phylogenies throughout the genomes of this species. Most of these genes including the "core" set of genes and horizontally transferred genes showed at least one recombination event. Taking into account the relationship between the nucleotide diversity and the minimum number of recombination events per nucleotide, we evaluated the recombination rate in every gene. The rate appears constant across the genome, but genes with a particularly high or low recombination rate were detected. Interestingly, genes with high recombination included those for DNA transformation and for basic cellular functions, such as biosynthesis and metabolism. Several highly divergent genes with a high recombination rate included those for host interaction, such as outer membrane proteins and lipopolysaccharide synthesis. These results provide a global picture of genome-wide distribution of outcrossing homologous recombination in a bacterial species for the first time, to our knowledge, and illustrate how a species can be shaped by mutual homologous recombination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.