ArticleEnvironmental health perspectives2012
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies.BMC public health · 2024Pooled it
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- Environmental toxicants and autism spectrum disorders: a systematic review.Translational psychiatry · 2014Pooled it
- The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery.Stem cells translational medicine · 2014Trial
- Association of cumulative early medical events and neurodevelopmental conditions through a common latent factor-A population-based twin study.JCPP advances · 2026Article
- Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases.bioRxiv : the preprint server for biology · 2025Article
- The Long and Winding Road to Understanding Autism.NeuroSci · 2025Review
- Characterization of gut microbiota on gender and age groups bias in Thai patients with autism spectrum disorder.Scientific reports · 2025Article
- Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data.Frontiers in pharmacology · 2025Article
- Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood.Neurotoxicology · 2024Article
- Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood.bioRxiv : the preprint server for biology · 2024Article
- Article
- Environmental Influences on Individuals with Autistic Spectrum Disorders with Special Emphasis on Seasonality: An Overview.Children (Basel, Switzerland) · 2023Review
- Perinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral deficits associated with neurodevelopmental disorders.Cell biology and toxicology · 2023Article
- Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.Journal of autism and developmental disorders · 2023Article
- National screening for Egyptian children aged 1 year up to 12 years at high risk of Autism and its determinants: a step for determining what ASD surveillance needs.BMC psychiatry · 2023Article
- Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023Review
- Linking Soil Microbial Diversity to Modern Agriculture Practices: A Review.International journal of environmental research and public health · 2022Review
- Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Review.International journal of environmental research and public health · 2021Review
- Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAutism spectrum disorders (ASDs) have been increasing in many parts of the world and a portion of cases are attributable to environmental exposures. Conclusive replicated findings have yet to appear on any specific exposure; however, mounting evidence suggests gestational pesticides exposures are strong candidates. Because multiple developmental processes are implicated in ASDs during gestation and early life, biological plausibility is more likely if these agents can be shown to affect core pathophysiological features.
objectivesOur objectives were to examine shared mechanisms between autism pathophysiology and the effects of pesticide exposures, focusing on neuroexcitability, oxidative stress, and immune functions and to outline the biological correlates between pesticide exposure and autism risk.
methodsWe review and discuss previous research related to autism risk, developmental effects of early pesticide exposure, and basic biological mechanisms by which pesticides may induce or exacerbate pathophysiological features of autism. DISCUSSION: On the basis of experimental and observational research, certain pesticides may be capable of inducing core features of autism, but little is known about the timing or dose, or which of various mechanisms is sufficient to induce this condition.
conclusionsIn animal studies, we encourage more research on gene × environment interactions, as well as experimental exposure to mixtures of compounds. Similarly, epidemiologic studies in humans with exceptionally high exposures can identify which pesticide classes are of greatest concern, and studies focused on gene × environment are needed to determine if there are susceptible subpopulations at greater risk from pesticide exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.