ArticleBMC research notes2012
Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
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- Optical Emission Spectroscopy for the Real-Time Identification of Malignant Breast Tissue.Diagnostics (Basel, Switzerland) · 2024Article
- Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals.Frontiers in immunology · 2024Review
- Biomineralogical signatures of breast microcalcifications.Science advances · 2023Article
- Methodology for the Implementation of Internal Standard to Laser-Induced Breakdown Spectroscopy Analysis of Soft Tissues.Sensors (Basel, Switzerland) · 2021Article
- Comparison of Elemental Anomalies Following Implantation of Different Cell Lines of Glioblastoma Multiforme in the Rat Brain: A Total Reflection X-ray Fluorescence Spectroscopy Study.ACS chemical neuroscience · 2020Article
- Environmental chemicals, breast cancer progression and drug resistance.Environmental health : a global access science source · 2020Review
- Assessment of YKL-40, lipid profile, antioxidant status, and some trace elements in benign and malignant breast proliferation.Molecular biology reports · 2020Article
- Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival.Scientific reports · 2020Article
- Article
- A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer.Caspian journal of internal medicine · 2020Review
- Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients.Nutrients · 2018Article
- Determining Serum Zinc and Magnesium Levels in Hemodialysis Patients Could be Helpful for Clinicians.Indian journal of clinical biochemistry : IJCB · 2017Article
- Heavy metals effect on breast cancer progression.Journal of occupational medicine and toxicology (London, England) · 2017Article
- Concentration Study of High Sensitive C - reactive Protein and some Serum Trace Elements in Patients with Benign and Malignant Breast Tumor.International journal of hematology-oncology and stem cell research · 2015Article
- Zinc distribution within breast cancer tissue: A possible marker for histological grading?Journal of cancer research and clinical oncology · 2015Article
- Screening of trace elements in hair of the female population with different types of cancers in Wielkopolska region of Poland.TheScientificWorldJournal · 2014Article
- Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms.Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe application and better understanding of traditional and new breast tumor biomarkers and prognostic factors are increasing due to the fact that they are able to identify individuals at high risk of breast cancer, who may benefit from preventive interventions. Also, biomarkers can make possible for physicians to design an individualized treatment for each patient. Previous studies showed that trace elements (TEs) determined by X-Ray Fluorescence (XRF) techniques are found in significantly higher concentrations in neoplastic breast tissues (malignant and benign) when compared with normal tissues. The aim of this work was to evaluate the potential of TEs, determined by the use of the Energy Dispersive X-Ray Fluorescence (EDXRF) technique, as biomarkers and prognostic factors in breast cancer.
methodsBy using EDXRF, we determined Ca, Fe, Cu, and Zn trace elements concentrations in 106 samples of normal and breast cancer tissues. Cut-off values for each TE were determined through Receiver Operating Characteristic (ROC) analysis from the TEs distributions. These values were used to set the positive or negative expression. This expression was subsequently correlated with clinical prognostic factors through Fisher's exact test and chi-square test. Kaplan Meier survival curves were also evaluated to assess the effect of the expression of TEs in the overall patient survival.
resultsConcentrations of TEs are higher in neoplastic tissues (malignant and benign) when compared with normal tissues. Results from ROC analysis showed that TEs can be considered a tumor biomarker because, after establishing a cut-off value, it was possible to classify different tissues as normal or neoplastic, as well as different types of cancer.The expression of TEs was found statistically correlated with age and menstrual status. The survival curves estimated by the Kaplan-Meier method showed that patients with positive expression for Cu presented a poor overall survival (p < 0.001).
conclusionsThis study suggests that TEs expression has a great potential of application as a tumor biomarker, once it was revealed to be an effective tool to distinguish different types of breast tissues and to identify the difference between malignant and benign tumors. The expressions of all TEs were found statistically correlated with well-known prognostic factors for breast cancer. The element copper also showed statistical correlation with overall survival.
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