ArticleJournal of clinical hypertension (Greenwich, Conn.)2012
Prediction of primary vs secondary hypertension in children.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis.The Journal of pediatrics · 2022Pooled it
- Hypertension in Children and Adolescents: A Position Statement From a Panel of Multidisciplinary Experts Coordinated by the French Society of Hypertension.Frontiers in pediatrics · 2021Pooled it
- Updated Guideline May Improve the Recognition and Diagnosis of Hypertension in Children and Adolescents; Review of the 2017 AAP Blood Pressure Clinical Practice Guideline.Current hypertension reports · 2017Pooled it
- Secular trends in society-, school-, and individual-level factors related to physical activity and their associations with elevated blood pressure among 0.6 million children and adolescents.Chinese medical journal · 2026Article
- Global trends and geographic variations of hypertension in childhood and adolescence 1990-2021: a systematic analysis of the Global Burden of Disease Study 2021.Clinical hypertension · 2026Article
- Current etiology of hypertension in European children - factors associated with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2025Article
- Investigations for diagnosis of secondary hypertension in children: yield and costs.Pediatric nephrology (Berlin, Germany) · 2025Article
- Secondary Hypertension in Children-Identifying and Investigating at Risk Children.Current hypertension reports · 2025Review
- Prevalence and factors associated with hypertension among children attending pre-schools in Dar es Salaam, Tanzania.Italian journal of pediatrics · 2025Article
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.Kidney research and clinical practice · 2025Article
- Pediatric Hypertension: A Condition That Matters.Children (Basel, Switzerland) · 2024Review
- Yield of diagnostic testing in evaluating etiology and end organ effects of pediatric hypertension.Pediatric nephrology (Berlin, Germany) · 2024Article
- Diagnostic evaluation of the hypertensive child.Pediatric nephrology (Berlin, Germany) · 2024Article
- Association of Newborn Telomere Length With Blood Pressure in Childhood.JAMA network open · 2022Article
- Efficacy and Safety of Intravenous Labetalol in Acute Hypertensive Crisis in Children.Indian journal of pediatrics · 2022Article
- Characteristics of pediatric inpatients with primary and secondary hypertension.Pediatric investigation · 2021Article
- Clinical Characteristics and Factors Associated With Hypertension in 205 Hospitalized Children: A Single-Center Study in Southwest China.Frontiers in pediatrics · 2021Article
- Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity.Gland surgery · 2020Review
- Essential hypertension in children, a growing worldwide problem.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Review
- Epidemiology of Childhood Onset Essential Hypertension.Journal of human hypertension · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite current guidelines, variability exists in the workup of hypertensive children due to physician preferences. The study evaluates primary vs secondary hypertension diagnosis from investigations routinely performed in hypertensive children. This retrospective study included children 5 to 19 years with primary and secondary hypertension. The proportions of abnormal laboratory and imaging tests were compared between primary and secondary hypertension groups. Risk factors for primary vs secondary hypertension were evaluated by logistic regression and likelihood function analysis. Patients with secondary hypertension were younger (5-12 years) and had a higher proportion of abnormal creatinine, renal ultrasound, and echocardiogram findings. There was no significant difference in abnormal results of thyroid function, urine catecholamines, plasma renin, and aldosterone. Abnormal renal ultrasound findings and age were predictors of secondary hypertension by regression and likelihood function analysis. Children aged 5 to 12 years with abnormal renal ultrasound findings and high diastolic blood pressures are at higher risk for secondary hypertension that requires detailed evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.