ArticleBMC medical research methodology2012
Transformations of summary statistics as input in meta-analysis for linear dose-response models on a logarithmic scale: a methodology developed within EURRECA.
Article in BMC medical research methodology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- The relationship between zinc intake and growth in children aged 1-8 years: a systematic review and meta-analysis.European journal of clinical nutrition · 2015Pooled it
- A statistical method to base nutrient recommendations on meta-analysis of intake and health-related status biomarkers.PloS one · 2014Pooled it
- Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation.Nutrition journal · 2012Pooled it
- The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis.Nutrients · 2012Pooled it
- Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment.European journal of clinical nutrition · 2014Trial
- Re-expressing coefficients from regression models for inclusion in a meta-analysis.BMC medical research methodology · 2024Article
- The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations.BMC medical research methodology · 2018Article
- Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses.Journal of nutrition and metabolism · 2013Article
- Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis.Journal of nutrition and metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo derive micronutrient recommendations in a scientifically sound way, it is important to obtain and analyse all published information on the association between micronutrient intake and biochemical proxies for micronutrient status using a systematic approach. Therefore, it is important to incorporate information from randomized controlled trials as well as observational studies as both of these provide information on the association. However, original research papers present their data in various ways.
methodsThis paper presents a methodology to obtain an estimate of the dose-response curve, assuming a bivariate normal linear model on the logarithmic scale, incorporating a range of transformations of the original reported data.
resultsThe simulation study, conducted to validate the methodology, shows that there is no bias in the transformations. Furthermore, it is shown that when the original studies report the mean and standard deviation or the geometric mean and confidence interval the results are less variable compared to when the median with IQR or range is reported in the original study.
conclusionsThe presented methodology with transformations for various reported data provides a valid way to estimate the dose-response curve for micronutrient intake and status using both randomized controlled trials and observational studies.
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Registered trials
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