Evidence map›Paper›PMID 22533466›Full record

ArticleMetabolic syndrome and related disorders2012

Opportunities for using lipoprotein subclass profile by nuclear magnetic resonance spectroscopy in assessing insulin resistance and diabetes prediction.

Alexis C Frazier-Wood, W Timothy Garvey, Tara Dall, Robert Honigberg, Ray Pourfarzib

Open access · greenAbstract read
In one paragraph

Article in Metabolic syndrome and related disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Genetics of non-conventional lipoprotein fractions.Current genetic medicine reports · 2015
    Article
  10. Observational
  11. Article
  12. Article
  13. Sex-specific associations between screen time and lipoprotein subfractions.International journal of sport nutrition and exercise metabolism · 2014
    Article
  14. New tools for weight-loss therapy enable a more robust medical model for obesity treatment: rationale for a complications-centric approach.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Alexis C Frazier-WoodDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
W Timothy Garvey
Tara Dall
Robert Honigberg
Ray Pourfarzib
AndroScience (United States) · USBirmingham VA Medical Center · USUniversity of Alabama at Birmingham · USUtah AIDS Foundation · US

Funding

Genetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9M
UAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4M
NR4A Orphan Receptors And Insulin ResistanceR01DK083562 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2009 to 2012
$2.1M
CSRD VA I01 CX000432NHLBI NIH HHS U01HL072524-04NIDDK NIH HHS DK-038764NIDDK NIH HHS DK-083562NIDDK NIH HHS P60-DK079626NIDDK NIH HHS R01 DK083562
6 · The paper itself

Abstract

The incidence of type 2 diabetes mellitus (T2DM) has reached epidemic levels, and current trends indicate that its prevalence will continue to rise. The development of T2DM can be delayed by several years, and may even be prevented, by identifying individuals at risk for T2DM and treating them with lifestyle modification and/or pharmacological therapies. There are a number of methods available for assessing the insulin resistance (IR) that characterizes, and is the precursor to, T2DM. However, current clinical methods for assessing IR, based on measures of plasma glucose and/or insulin are either laborious and time-consuming or show a low specificity. IR manifests its earliest measurable abnormalities through changes in lipoproteins, and thus we propose that by examining lipoprotein subclass profile, it may be possible to alert physicians and patients to a heightened risk of developing diabetes. This will allow us to institute appropriate lifestyle changes and treatment potentially to delay the onset or possibly prevent the progression to diabetes.

Indexed as

Insulin ResistanceAdultBlood GlucoseBody WeightDiabetes MellitusDisease ProgressionFemaleHumansLife StyleLipoproteinsMagnetic Resonance SpectroscopyMaleMiddle AgedProportional Hazards ModelsRiskRisk FactorsBlood GlucoseLipoproteins

Identifiers

PMID22533466
PMCPMC3409454
OpenAlexW1981194639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.