ArticleRejuvenation research2012
Hormone supplementation during aging: how much and when?
Article in Rejuvenation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques.Neurobiology of aging · 2023Article
- The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
- Postmenopausal cognitive changes and androgen levels in the context of apolipoprotein E polymorphism.Archives of medical science : AMS · 2017Article
- Androgen supplementation during aging: development of a physiologically appropriate protocol.Rejuvenation research · 2014Article
- Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.Frontiers in endocrinology · 2014Article
- Causes and consequences of age-related steroid hormone changes: insights gained from nonhuman primates.Journal of neuroendocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.