ArticleBritish journal of clinical pharmacology2012
Sex differences in cardiovascular drug-induced adverse reactions causing hospital admissions.
Article in British journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of natriuresis-guided diuretic therapy in men and women with acute heart failure: insights from PUSH-AHF.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Trial
- Sex-related similarities and differences in responses to heart failure therapies.Nature reviews. Cardiology · 2024Review
- The influence of age, gender and pharmacogenetic profiles on the perspective on medicines in the German EMPAR study.PloS one · 2024Observational
- Sex Differences in Heart Failure: What Do We Know?Journal of cardiovascular development and disease · 2023Review
- Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis.Nature reviews. Rheumatology · 2022Review
- Construction of a femininity score in the UK Biobank and its association with angina diagnosis prior to myocardial infarction.Scientific reports · 2022Article
- Are there sex differences in potentially inappropriate prescribing in adults with multimorbidity?Journal of the American Geriatrics Society · 2021Article
- Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Risk of Hospitalization Associated with Cardiovascular Medications in the Elderly Italian Population: A Nationwide Multicenter Study in Emergency Departments.Frontiers in pharmacology · 2020Article
- Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1).Physiological reports · 2019Article
- Sex-Gender Variable: Methodological Recommendations for Increasing Scientific Value of Clinical Studies.Cells · 2019Review
- Sex Differences in the Management of Advanced Heart Failure.Current treatment options in cardiovascular medicine · 2018Review
- Withdrawal of prenylamine: perspectives on pharmacological, clinical and regulatory outcomes following the first QT-related casualty.Therapeutic advances in drug safety · 2018Review
- Categorization and association analysis of risk factors for adverse drug events.European journal of clinical pharmacology · 2018Review
- Gender in Endocrine Diseases: Role of Sex Gonadal Hormones.International journal of endocrinology · 2018Review
- Retrospective Study of Reported Adverse Events Due to Complementary Health Products in Singapore From 2010 to 2016.Frontiers in medicine · 2018Article
- Sex differences in drugs: the development of a comprehensive knowledge base to improve gender awareness prescribing.Biology of sex differences · 2017Article
- Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China.Scientific reports · 2017Article
- CUA guideline on adult overactive bladder.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017Article
- Adverse drug reactions to anticoagulants in Spain: analysis of the Spanish National Hospital Discharge Data (2010-2013).BMJ open · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsCardiovascular disease in women is often underestimated. The effects of cardiovascular drugs differ between the sexes because of pharmacokinetic and pharmacodynamic differences. Adverse drug reactions (ADRs) within these drug classes may have serious consequences, leading to hospital admission. We aimed to study differences between men and women in hospital admissions for ADRs due to cardiovascular drugs.
methodsWe conducted a nationwide study of all hospital admissions between 2000 and 2005 with data from the Dutch National Medical Register. Relative risks were calculated of hospital admissions due to ADRs to the different cardiovascular drug groups for women compared with men. By an ecological design, risks were adjusted for the total number of Dutch inhabitants and the total number of prescriptions.
resultsIn total, 14 207 of the hospital admissions (34% of all ADR-related admissions) were attributed to cardiovascular drugs [7690 in women (54%; 95% confidence interval 53-55%)]. 'Anticoagulants and salicylates' (n= 8988), 'high- and low-ceiling diuretics' (n= 2242) and 'cardiotonic glycosides' (n= 932) were responsible for the majority of the ADR-related hospital admissions. The most pronounced sex differences were seen in users of low-ceiling diuretics (relative risk 4.02; 95% confidence interval 3.12-5.19), cardiotonic glycosides (relative risk 2.38; 95% confidence interval 2.06-2.74), high-ceiling diuretics (relative risk 2.10; 95% confidence interval 1.91-2.32) and coronary vasodilators (relative risk 0.77; 95% confidence interval 0.65-0.91).
conclusionsClear sex differences exist in ADRs requiring hospital admission for different cardiovascular drug groups. Sex differences should be taken into account in the prescription and evaluation of drugs.
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