ReviewCancer metastasis reviews1990
Cell-matrix interactions during tumor invasion.
Review in Cancer metastasis reviews, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Elastin peptides regulate HT-1080 fibrosarcoma cell migration and invasion through an Hsp90-dependent mechanism.British journal of cancer · 2014Article
- Physiopathology of spine metastasis.International journal of surgical oncology · 2011Article
- Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane-type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line.Clinical & experimental metastasis · 1998Article
- Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors.Journal of mammary gland biology and neoplasia · 1998Review
- Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma.Pathology oncology research : POR · 1998Article
- Hyaluronan: RHAMM mediated cell locomotion and signaling in tumorigenesis.Journal of neuro-oncology · 1995Review
- The role of fibroblasts in tumor behavior.Cancer metastasis reviews · 1995Review
- From passive diffusion to active cellular migration in mathematical models of tumour invasion.Acta biotheoretica · 1995Article
- Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity.The Journal of cell biology · 1994Article
- Inhibition of collagenolytic activity relates to quantitative reduction of invasion in vitro in a c-Ha-ras transfected glial cell line.Journal of neuro-oncology · 1994Article
- Cathepsin B expression in tumour cells and laminin distribution in pulmonary adenocarcinoma.Journal of clinical pathology · 1993Article
- Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells.The American journal of pathology · 1992Article
- Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases.Cancer metastasis reviews · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This manuscript reviews the molecular aspects of tumor cell invasion of extracellular matrix. The changes in cell:substrate and cell:cell receptors that characterize motile cells are discussed for their importance not only in mediating invasive cell behavior, but also as diagnostic markers for invasive potential. Autocrine motility and scatter factors probably have key roles in initiating migratory behavior, while specific and non-specific extracellular matrix alterations can facilitate cell locomotion. The manuscript reviews reported changes, such as induction of cell motility, matrix degrading enzymes, and invasive/metastatic potential, which can follow transfection with ras oncogenes, and details the key roles of metalloproteinases, heparanase, and plasminogen activator in matrix degradation. Enzymatic inhibitors of initial steps in extracellular matrix degradation, such as rTIMP, and synthetic blockers of adhesive steps in tumor cell invasion represent types of reagent with potential as anti-metastatic agents. Their potential usefulness may be increased if they can be incorporated into a novel, long-term, non-traditional delivery system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.