ReviewDeutsches Arzteblatt international2012
Achalasia--a disease of unknown cause that is often diagnosed too late.
Review in Deutsches Arzteblatt international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Laparoscopic Heller myotomy or pneumatic dilatation in achalasia: results of a prospective, randomized study with at least a decade of follow-up.Surgical endoscopy · 2021Trial
- Treatment of achalasia with laparoscopic myotomy or pneumatic dilatation: long-term results of a prospective, randomized study.World journal of surgery · 2015Trial
- Two pediatric type II achalasia cases complicated by candidal and eosinophilic esophagitis: Successful peroral endoscopic myotomy treatment.JPGN reports · 2026Article
- A frameshift variant in FAM129C contributes to achalasia through B cell responses against the GABANature communications · 2026Article
- Role of SIRT3 in digestive system diseases and therapeutic prospects (Review).International journal of molecular medicine · 2026Review
- Achalasia: Physician Practices and Knowledge in Türkiye.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- What worsens swallowing in esophageal achalasia? Insights from patient-reported outcomes.Frontiers in nutrition · 2026Article
- First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia.Gut · 2025Article
- Postoperative Pain Management Strategies Following Peroral Endoscopic Myotomy (POEM): A Review.Journal of pain research · 2025Review
- Delayed diagnosis and treatment of achalasia: a case report.Journal of medical case reports · 2024Article
- Anesthetic management of a patient with achalasia, a disease with a considerable risk for aspiration under anesthesia.JA clinical reports · 2023Article
- Article
- Burn Pits: A Possible Trigger for Achalasia.Cureus · 2023Article
- SIRT3 activation promotes enteric neurons survival and differentiation.Scientific reports · 2022Article
- Clinical Usefulness of Endoscopy, Barium Fluoroscopy, and Chest Computed Tomography for the Correct Diagnosis of Achalasia.Internal medicine (Tokyo, Japan) · 2020Article
- Durability of pneumatic dilation monotherapy in treatment-naive achalasia patients.BMC gastroenterology · 2019Article
- [Anesthesia in gastrointestinal endoscopy: peroral endoscopic myotomy].Der Anaesthesist · 2019Review
- Validation of new Japanese classification system for esophageal achalasia.Esophagus : official journal of the Japan Esophageal Society · 2019Article
- Is There Any Evidence for a Viral Cause in Achalasia?Middle East journal of digestive diseases · 2018Article
- MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients.Experimental and therapeutic medicine · 2017Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMany physicians are inadequately familiar with the clinical features of achalasia. Often, it is not diagnosed until years after the symptoms arise. This is unfortunate, because a delay in diagnosis worsens the prognosis.
methodsSelective review of the literature.
resultsAchalasia has a lifetime prevalence of 1:10 000. It is a neurodegenerative disorder in which the neurons of the myenteric plexus are lost, leading to dysfunction of the lower esophageal sphincter and to a derangement of esophageal peristalsis. In the final stage of achalasia, esophageal motility is irreversibly impaired, and complications ensue because of the retention of food that is no longer transported into the stomach. Aspiration causes pulmonary disturbances in up to half of all patients with achalasia. There may also be inflammation of the esophageal mucosa (retention esophagitis); this, in turn, is a risk factor for esophageal cancer, which arises in 4% to 6% of patients. The cause of achalasia is not fully known, but autoimmune processes appear to be involved in patients with a genetic susceptibility to the disease.
conclusionAchalasia should be diagnosed as early as possible, so that complications can be prevented. In addition, guidelines should be established for cancer prevention in achalasia patients. Currently ongoing studies of the molecular causes of achalasia will probably help us understand its pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.