ArticlePLoS genetics2012
Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Antimicrobial peptoids pass rapidly through bacterial membranes and flocculate ribosomes and DNA: A single-cell fluorescence study.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence for biomolecular condensates formed by the Escherichia coli MatP protein in spatiotemporal regulation of the bacterial cell division cycle.International journal of biological macromolecules · 2025Article
- Spatio-temporal organization of theEcoSal Plus · 2024Review
- Activity of MukBEF for chromosome management ineLife · 2024Article
- Interpretation of organizational role of proteins on E. coli nucleoid via Hi-C integrated model.Biophysical journal · 2023Article
- Long-term effects of the proline-rich antimicrobial peptide Oncocin112 on theThe Journal of biological chemistry · 2020Article
- Chromosome organization in bacteria: mechanistic insights into genome structure and function.Nature reviews. Genetics · 2020Review
- Chromosome Segregation Proteins as Coordinators of Cell Cycle in Response to Environmental Conditions.Frontiers in microbiology · 2020Review
- Unstable chromosome rearrangements inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.Nucleic acids research · 2019Article
- An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.BMC biotechnology · 2017Article
- Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains.PLoS genetics · 2017Article
- Colocalization of distant chromosomal loci in space in E. coli: a bacterial nucleolus.Genes & development · 2016Article
- The MaoP/maoS Site-Specific System Organizes the Ori Region of the E. coli Chromosome into a Macrodomain.PLoS genetics · 2016Article
- Coevolution of the Organization and Structure of Prokaryotic Genomes.Cold Spring Harbor perspectives in biology · 2016Review
- Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity.PLoS genetics · 2015Article
- Single-cell, real-time detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bacterial chromosome organization and segregation.Annual review of cell and developmental biology · 2015Review
- The bacterial nucleoid: nature, dynamics and sister segregation.Current opinion in microbiology · 2014Review
- Cell cycle regulation by the bacterial nucleoid.Current opinion in microbiology · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of the Escherichia coli chromosome into a ring composed of four macrodomains and two less-structured regions influences the segregation of sister chromatids and the mobility of chromosomal DNA. The structuring of the terminus region (Ter) into a macrodomain relies on the interaction of the protein MatP with a 13-bp target called matS repeated 23 times in the 800-kb-long domain. Here, by using a new method that allows the transposition of any chromosomal segment at a defined position on the genetic map, we reveal a site-specific system that restricts to the Ter region a constraining process that reduces DNA mobility and delays loci segregation. Remarkably, the constraining process is regulated during the cell cycle and occurs only when the Ter MD is associated with the division machinery at mid-cell. The change of DNA properties does not rely on the presence of a trans-acting mechanism but rather involves a cis-effect acting at a long distance from the Ter region. Two specific 12-bp sequences located in the flanking Left and Right macrodomains and a newly identified protein designated YfbV conserved with MatP through evolution are required to impede the spreading of the constraining process to the rest of the chromosome. Our results unravel a site-specific system required to restrict to the Ter region the consequences of anchoring the Ter MD to the division machinery.
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