ArticleAnnals of the rheumatic diseases2012
Patient's global assessment of disease activity and patient's assessment of general health for rheumatoid arthritis activity assessment: are they equivalent?
Article in Annals of the rheumatic diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- A systematic review with meta-analysis of the effects of smoking cessation strategies in patients with rheumatoid arthritis.PloS one · 2022Pooled it
- Dose-Response Effects of Tai Chi and Physical Therapy Exercise Interventions in Symptomatic Knee Osteoarthritis.PM & R : the journal of injury, function, and rehabilitation · 2018Trial
- Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure.Osteoarthritis and cartilage · 2018Trial
- Mindfulness Is Associated With Treatment Response From Nonpharmacologic Exercise Interventions in Knee Osteoarthritis.Archives of physical medicine and rehabilitation · 2017Trial
- Total Wrist Arthrodesis Using a Wrist Fusion Rod for the Dislocated Rheumatoid Wrist.Journal of hand surgery global online · 2026Article
- Patient global assessment in rheumatoid arthritis: general health and disease activity are not interchangeable.Rheumatology (Oxford, England) · 2026Article
- Article
- Relationships between patient and physician global assessments in anti-neutrophil cytoplasmic antibody-associated vasculitis.Clinical rheumatology · 2025Observational
- The steroid-sparing effect of JAK inhibitors across multiple patient populations.Frontiers in immunology · 2024Article
- RheuMetric Quantitative 0 to 10 Physician Estimates of Inflammation, Damage, and Distress in Rheumatoid Arthritis: Validation Against Reference Measures.ACR open rheumatology · 2023Article
- Remission or Not Remission, That's the Question: Shedding Light on Remission and the Impact of Objective and Subjective Measures Reflecting Disease Activity in Rheumatoid Arthritis.Rheumatology and therapy · 2022Article
- Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross-sectional study.Advances in rheumatology (London, England) · 2021Article
- Comparison of the effects of baricitinib and tocilizumab on disease activity in patients with rheumatoid arthritis: a propensity score matching analysis.Clinical rheumatology · 2021Article
- Limiting factors to Boolean remission differ between autoantibody-positive and -negative patients in early rheumatoid arthritis.Therapeutic advances in musculoskeletal disease · 2021Article
- What Does the Patient Global Health Assessment in Rheumatoid Arthritis Really Tell Us? Contribution of Specific Dimensions of Health-Related Quality of Life.Arthritis care & research · 2020Observational
- Secular changes in the progression of clinical markers and patient-reported outcomes in early rheumatoid arthritis.Rheumatology (Oxford, England) · 2020Observational
- Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28.Rheumatology international · 2018Article
- Influence of the different "patient global assessment" formulations on disease activity score by different indices in rheumatoid arthritis.Clinical rheumatology · 2018Article
- Phrasing of the patient global assessment in the rheumatoid arthritis ACR/EULAR remission criteria: an analysis of 967 patients from two databases of early and established rheumatoid arthritis patients.Clinical rheumatology · 2018Article
- Could Activity Modifications Indicate Physical Decline Among Adults With Symptomatic Knee Osteoarthritis?American journal of physical medicine & rehabilitation · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 20 institutions in 17 countries.
Funding
Abstract
objectivesTo assess (A) determinants of patient's global assessment of disease activity (PTGL) and patient's assessment of general health (GH) scores of rheumatoid arthritis (RA) patients; (B) whether they are equivalent as individual variables; and (C) whether they may be used interchangeably in calculating common RA activity assessment composite indices.
methodsData of 7023 patients from 30 countries in the Quantitative Standard Monitoring of Patients with RA (QUEST-RA) was analysed. PTGL and GH determinants were assessed by mixed-effects analyses of covariance models. PTGL and GH equivalence was determined by Bland-Altman 95% limits of agreement (BALOA) and Lin's coefficient of concordance (LCC). Concordance between PTGL and GH based Disease Activity Score 28 (DAS28), Clinical Disease Activity Index (CDAI) and Routine Assessment of Patient Index Data 3 (RAPID3) indices were calculated using LCC, and the level of agreement in classifying RA activity in four states (remission, low, moderate, high) using κ statistics.
resultsSignificant differences in relative and absolute contribution of RA and non-RA related variables in PTGL and GH ratings were noted. LCC of 0.64 and BALOA of -4.41 to 4.54 showed that PTGL and GH are not equivalent. There was excellent concordance (LCC 0.95-0.99) for PTGL and GH based DAS28, CDAI and RAPID3 indices, and >80% absolute agreement (κ statistics 0.75-0.84) in RA activity state classification for all three indices.
conclusionsPTGL and GH ratings differ in their determinants. Although they are individually not equivalent, they may be used interchangeably for calculating composite indices for RA activity assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.