ArticleNucleic acids research2012
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- ALKBH2 promotes the Warburg effect and bladder cancer progression under hypoxic conditions via the PI3K/AKT pathway.Clinical and experimental medicine · 2026Article
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- Multiple Physiological and Biochemical Functions of Ascorbic Acid in Plant Growth, Development, and Abiotic Stress Response.International journal of molecular sciences · 2024Review
- Phylogenetic and functional analyses ofmSphere · 2024Article
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- Roles of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily in the Flavonoid Pathway: A Review of the Functional Diversity of F3H, FNS I, FLS, and LDOX/ANS.Molecules (Basel, Switzerland) · 2021Review
- DNA Methylation on N6-Adenine Regulates the Hyphal Development during Dimorphism in the Early-Diverging FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Mechanisms of Genome Maintenance in Plants: Playing It Safe With Breaks and Bumps.Frontiers in genetics · 2021Review
- Prediction of regulatory long intergenic non-coding RNAs acting in trans through base-pairing interactions.BMC genomics · 2019Article
- The Origin and Evolution of Plant Flavonoid Metabolism.Frontiers in plant science · 2019Review
- Article
- ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.Cell death & disease · 2017Article
- Article
- Involvement of Iron-Containing Proteins in Genome Integrity in Arabidopsis Thaliana.Genome integrity · 2015Review
- Nucleic acid oxidation in DNA damage repair and epigenetics.Chemical reviews · 2014Review
- Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism.Frontiers in plant science · 2014Review
- DNA repair by reversal of DNA damage.Cold Spring Harbor perspectives in biology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Escherichia coli AlkB protein (EcAlkB) is a DNA repair enzyme which reverses methylation damage such as 1-methyladenine (1-meA) and 3-methylcytosine (3-meC). The mammalian AlkB homologues ALKBH2 and ALKBH3 display EcAlkB-like repair activity in vitro, but their substrate specificities are different, and ALKBH2 is the main DNA repair enzyme for 1-meA in vivo. The genome of the model plant Arabidopsis thaliana encodes several AlkB homologues, including the yet uncharacterized protein AT2G22260, which displays sequence similarity to both ALKBH2 and ALKBH3. We have here characterized protein AT2G22260, by us denoted ALKBH2, as both our functional studies and bioinformatics analysis suggest it to be an orthologue of mammalian ALKBH2. The Arabidopsis ALKBH2 protein displayed in vitro repair activities towards methyl and etheno adducts in DNA, and was able to complement corresponding repair deficiencies of the E. coli alkB mutant. Interestingly, alkbh2 knock-out plants were sensitive to the methylating agent methylmethanesulphonate (MMS), and seedlings from these plants developed abnormally when grown in the presence of MMS. The present study establishes ALKBH2 as an important enzyme for protecting Arabidopsis against methylation damage in DNA, and suggests its homologues in other plants to have a similar function.
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