ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2012
The amount of periosteal apposition required to maintain bone strength during aging depends on adult bone morphology and tissue-modulus degradation rate.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- An index of net bone formation relative to resorption is associated with incident fracture during the menopause transition and postmenopause.JBMR plus · 2026Article
- Associations of muscle strength and functional power with longitudinal change in HR-pQCT bone parameters: the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: The Study of Muscle, Mobility and Aging (SOMMA).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Trajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years.Science advances · 2025Article
- Skeletal risk factors for postoperative complications in older men undergoing spinal fusion surgery.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Impact of outer width of the metacarpal diaphysis on the identification of low bone mass in children.PloS one · 2025Article
- Piezo1 opposes age-associated cortical bone loss.Aging cell · 2023Article
- Low bone mineral density and its related factors in adults with congenital heart disease in Vietnam: A cross-sectional study.Health science reports · 2022Article
- Bringing Mechanical Context to Image-Based Measurements of Bone Integrity.Current osteoporosis reports · 2021Review
- Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats.Molecules (Basel, Switzerland) · 2021Article
- Age-related periosteal expansion at femoral neck among elderly women may maintain bending stiffness, but not femoral strength.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- External Bone Size Is a Key Determinant of Strength-Decline Trajectories of Aging Male Radii.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- The effect of growth rate on the three-dimensional orientation of vascular canals in the cortical bone of broiler chickens.Journal of anatomy · 2018Article
- Article
- Femoral Neck External Size but not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Sex-Differences in Skeletal Growth and Aging.Current osteoporosis reports · 2017Review
- Article
- Women Build Long Bones With Less Cortical Mass Relative to Body Size and Bone Size Compared With Men.Clinical orthopaedics and related research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although the continued periosteal apposition that accompanies age-related bone loss is a biomechanically critical target for prophylactic treatment of bone fragility, the magnitude of periosteal expansion required to maintain strength during aging has not been established. A new model for predicting periosteal apposition rate for men and women was developed to better understand the complex, nonlinear interactions that exist among bone morphology, tissue-modulus, and aging. Periosteal apposition rate varied up to eightfold across bone sizes, and this depended on the relationship between cortical area and total area, which varies with external size and among anatomical sites. Increasing tissue-modulus degradation rate from 0% to -4%/decade resulted in 65% to 145% increases in periosteal apposition rate beyond that expected for bone loss alone. Periosteal apposition rate had to increase as much as 350% over time to maintain stiffness for slender diaphyses, whereas robust bones required less than a 32% increase over time. Small changes in the amount of bone accrued during growth (ie, adult cortical area) affected periosteal apposition rate of slender bones to a much greater extent compared to robust bones. This outcome suggested that impaired bone growth places a heavy burden on the biological activity required to maintain stiffness with aging. Finally, sex-specific differences in periosteal apposition were attributable in part to differences in bone size between the two populations. The results indicated that a substantial proportion of the variation in periosteal expansion required to maintain bone strength during aging can be attributed to the natural variation in adult bone width. Efforts to identify factors contributing to variation in periosteal expansion will benefit from developing a better understanding of how to adjust clinical data to differentiate the biological responses attributable to size-effects from other genetic and environmental factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.