ArticleHippocampus2012
Interfering with Fos expression in rat perirhinal cortex impairs recognition memory.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits.Neuropharmacology · 2023Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- The Perirhinal Cortex Engages in Area and Layer-Specific Encoding of Item Dimensions.Frontiers in behavioral neuroscience · 2021Article
- Multi-level analyses of associative recognition memory: the whole is greater than the sum of its parts.Current opinion in behavioral sciences · 2020Review
- Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus.BioMed research international · 2018Article
- Recognition memory-induced gene expression in the perirhinal cortex: A transcriptomic analysis.Behavioural brain research · 2017Article
- Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory.Neuroepigenetics · 2017Article
- Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns.Hippocampus · 2016Article
- Cyclic GMP-mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice.Psychopharmacology · 2016Article
- Advances in the behavioural testing and network imaging of rodent recognition memory.Behavioural brain research · 2015Review
- In search of a recognition memory engram.Neuroscience and biobehavioral reviews · 2015Review
- Mapping parahippocampal systems for recognition and recency memory in the absence of the rat hippocampus.The European journal of neuroscience · 2014Article
- Contrasting networks for recognition memory and recency memory revealed by immediate-early gene imaging in the rat.Behavioral neuroscience · 2014Article
- Physical exercise during pregnancy improves object recognition memory in adult offspring.Neuroscience · 2014Article
- Article
- The neural basis of nonvisual object recognition memory in the rat.Behavioral neuroscience · 2013Article
- Anterior thalamic nuclei lesions in rats disrupt markers of neural plasticity in distal limbic brain regions.Neuroscience · 2012Article
- What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory.Neuropsychologia · 2012Review
- Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice.PloS one · 2012Article
- Distributed interactive brain circuits for object-in-place memory: A place for time?Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work has shown that immunohistochemical imaging of Fos protein is a reliable marker for changes in activity related to recognition memory in the perirhinal (PRH) cortex of the medial temporal lobe; however, whether PRH Fos expression is necessary for recognition memory had not been established. To investigate this potential requirement, antisense Fos oligodeoxynucleotide (ODN) was infused locally into PRH cortex to interfere with Fos production. As in previous studies, differential Fos expression produced by viewing novel or familiar visual stimuli was measured by immunohistochemistry: antisense Fos ODN infusion into PRH cortex disrupted the normal pattern of differential Fos expression in PRH cortex. The effect of antisense Fos ODN infusion into PRH cortex was therefore sought on recognition memory. Infusion before or immediately after acquisition impaired recognition memory for objects when the memory delay was 3 or 24 h, but not when the delay was 20 min, or when the ODN was infused before retrieval after a 24-h delay. The findings indicate a role for Fos in consolidation processes underlying long-term recognition memory for objects and establish that interfering with its expression impairs recognition memory. Antisense Fos ODN infusion also impaired object-in-place recognition memory. The results demonstrate that Fos is necessary for neuronal mechanisms in PRH cortex essential to recognition memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.