ReviewPediatric nephrology (Berlin, Germany)2012
Safety in glomerular numbers.
Review in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- Prevalence and risk factors for acute kidney injury at the diagnosis of juvenile idiopathic arthritis in children and its long-term implications for kidney health.Pediatric nephrology (Berlin, Germany) · 2026Article
- Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents.American journal of physiology. Renal physiology · 2026Article
- Prevalence and factors associated with acute kidney injury in children presenting to the emergency department with a first tonic-clonic seizure: an exploratory study.European journal of pediatrics · 2026Article
- Protecting Kidney Health in the First 1000 Days: The Pediatrician's Role in Safeguarding the Weakest.Diseases (Basel, Switzerland) · 2026Review
- Clinical Course and Considerations of a Stage G4 Chronic Kidney Disease Patient Who Successfully Initiated Dialysis During Pregnancy and Discontinued It Postpartum.The American journal of case reports · 2026Article
- Kidney involvement during the course of febrile urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2025Review
- Prediction of Possible Adverse Effects of Gestational Diabetes Mellitus on Maternal and Fetal Glomeruli by Urine and Amniotic Fluid Podocyte Degradation Products.Diagnostics (Basel, Switzerland) · 2024Article
- Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective.Journal of clinical medicine · 2024Article
- Kidney function evaluation in children and adolescents with obesity: a not-negligible need.European journal of pediatrics · 2024Review
- Mice with aAmerican journal of physiology. Renal physiology · 2024Article
- Hedgehog-GLI mediated control of renal formation and malformation.Frontiers in nephrology · 2023Review
- Early Renal Ultrasound in Patients with Congenital Solitary Kidney Can Guide Follow-Up Strategy Reducing Costs While Keeping Long-Term Prognostic Information.Journal of clinical medicine · 2022Article
- Compensatory Hypertrophy in Paediatric Patients with a Unilateral Ureteropelvic Junction Obstruction.European urology open science · 2021Article
- A Scoping Review of Life-Course Psychosocial Stress and Kidney Function.Children (Basel, Switzerland) · 2021Article
- p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.Life sciences · 2021Article
- Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study.Translational pediatrics · 2021Article
- Population Estimates of GFR and Risk Factors for CKD in Guatemala.Kidney international reports · 2021Article
- Evaluation of renal injury in children with a solitary functioning kidney.Turkish archives of pediatrics · 2021Article
- Long-term renal disease after prematurity or fetal growth restriction: who is at risk?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A low nephron number is, according to Brenner's hyperfiltration hypothesis, associated with hypertension, glomerular damage and proteinuria, and starts a vicious cycle that ends in renal failure over the long term. Nephron endowment is set during foetal life, and there is no formation of nephrons after 34-36 weeks of gestation, indicating that many factors before that time-point may have an impact on kidney development and reduce nephron numbers. Such factors include maternal malnutrition, stress, diseases, such as diabetes, uteroplacental insufficiency, maternal and neonatal drugs and premature birth. However, other congenital anomalies, such as renal hypoplasia, unilateral renal agenesis or multicystic dysplastic kidney, may also lead to a reduced nephron endowment, with an increased risk for hypertension, renal dysfunction and the need for renal replacement therapy. This review focuses on the causes and consequences of a low nephron endowment and will illustrate why there is safety in glomerular numbers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.