Evidence map›Paper›PMID 22531648›Full record

ArticleMedical care2013

Validation of electronic data on chemotherapy and hormone therapy use in HMOs.

Debra P Ritzwoller, Nikki Carroll, Thomas Delate, Maureen O'Keeffe-Rossetti, Paul A Fishman, Elizabeth T Loggers, Erin J Aiello Bowles, Jennifer Elston-Lafata, Mark C Hornbrook

Abstract readValidation Study
In one paragraph

Article in Medical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
13.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

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  8. The Adolescent and Young Adult (AYA) Horizon Study: An AYA Cancer Survivorship Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  9. Article
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  12. Health care improvement and survivorship priorities of colorectal cancer survivors: findings from the PORTAL colorectal cancer cohort survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  18. Predicting neutropenia risk in patients with cancer using electronic data.Journal of the American Medical Informatics Association : JAMIA · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Debra P Ritzwoller*The Institute for Health Research, Kaiser Permanente Colorado, Denver, CO †The Center for Health Research, Kaiser Permanente Northwest, Portland, OR ‡The Group Health Research Institute, Seattle, WA §Department of Social and Behavioral Health, School of Medicine, Virginia Commonwealth University, Richmond, VA ∥Henry Ford Health System, Detroit, MI.
Nikki Carroll
Thomas Delate
Maureen O'Keeffe-Rossetti
Paul A Fishman
Elizabeth T Loggers
Erin J Aiello Bowles
Jennifer Elston-Lafata
Mark C Hornbrook
Kaiser Permanente · USKaiser Permanente Washington Health Research Institute · USKaiser Permanente Center for Health Research · USVirginia Commonwealth University · US

Funding

The HMO Cancer Research Network (CRN)U19CA079689 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI WAGNER, EDWARD H · 1999 to 2011
$62.6M
Medical Care Burden of Cancer: System and Data IssuesR01CA114204 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HORNBROOK, MARK CHRISTOPHER · 2007 to 2010
$2.7M
Building CER Capacity: Aligning CRN, CMS, and State Resources to Map Cancer CareRC2CA148185 · NCI · DANA-FARBER CANCER INST · PI RITZWOLLER, DEBRA P, WEEKS, JANE C. · 2009 to 2009
$2.0M
NCI NIH HHS R01 CA114204NCI NIH HHS RC2 CA148185NCI NIH HHS U19 CA079689NCI NIH HHS U19 CA79689
6 · The paper itself

Abstract

backgroundMost data regarding medical care for cancer patients in the United States comes from Surveillance, Epidemiology and End Results-linked Medicare analyses of individuals aged 65 years or older and typically excludes Medicare Advantage enrollees.

objectivesTo assess the accuracy of chemotherapy and hormone therapy treatment data available through the Cancer Research Network's Virtual Data Warehouse (VDW). RESEARCH

designRetrospective, longitudinal cohort study. Medical record-abstracted, tumor registry-indicated treatments (gold standard) were compared with VDW-indicated treatments derived from health maintenance organization pharmacy, electronic medical record, and claim-based data systems. SUBJECTS: Enrollees aged 18 years and older diagnosed with incident breast, colorectal, lung, or prostate cancer from 2000 through 2007. MEASURES: Sensitivity, specificity, and positive predictive value were computed at 6 and 12 months after cancer diagnosis.

resultsApproximately 45% of all cancer cases (total N=23,800) were aged 64 years or younger. Overall chemotherapy sensitivity/specificities across the 3 health plans for incident breast, colorectal, lung, and prostate cancer cases were 95%/90%, 95%/93%, 93%/93%, and 85%/77%, respectively. With the exception of prostate cancer cases, overall positive predictive value ranged from 86% to 89%. Small variations in chemotherapy data accuracy existed due to cancer site and data source, whereas greater variation existed in hormone therapy capture across sites.

conclusionsStrong concordance exists between gold standard tumor registry measures of chemotherapy receipt and Cancer Research Network VDW data. Health maintenance organization VDW data can be used for a variety of studies addressing patterns of cancer care and comparative effectiveness research that previously could only be conducted among elderly Surveillance, Epidemiology and End Results-Medicare populations.

Indexed as

AdolescentAdultAgedAged, 80 and overAntineoplastic AgentsBreast NeoplasmsCohort StudiesColorectal NeoplasmsDatabases, FactualDrug TherapyElectronic Health RecordsFemaleHealth Maintenance OrganizationsHormonesHumansLongitudinal StudiesAntineoplastic AgentsHormones

Identifiers

PMID22531648
PMCPMC3406224
OpenAlexW2018717854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.