ArticleBritish journal of cancer2012
Incidence and possible pathogenesis of sentinel node micrometastases in ductal carcinoma in situ of the breast detected using molecular whole lymph node assay.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Outcomes in patients with non-invasive breast carcinoma.Cancer reports (Hoboken, N.J.) · 2023Article
- Trends in Axillary Surgery for Treating Ductal CarcinomaJournal of breast cancer · 2021Article
- Article
- A new molecular-based lymph node staging classification determines the prognosis of breast cancer patients.British journal of cancer · 2017Article
- Current approach and future perspective for ductal carcinoma in situ of the breast.Japanese journal of clinical oncology · 2017Review
- Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ.Cancer science · 2014Article
- Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay.British journal of cancer · 2013Article
- Reply: Isolated tumour cells and micrometastases in intraductal breast cancer: a simple mechanical question in some cases.British journal of cancer · 2013Article
- Isolated tumour cells and micrometastases in intraductal breast cancer: a simple mechanical question in some cases.British journal of cancer · 2013Article
- Detection of occult invasion in ductal carcinoma in situ of the breast with sentinel node metastasis.Cancer science · 2013Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogenesis of lymph node metastases in preinvasive breast cancer – ductal carcinoma in situ (DCIS) – remains controversial. The one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can assess a whole node and detect clinically relevant metastases. In this retrospective cohort study, we determined the performance of the OSNA assay in DCIS and the pathogenesis of node-positive DCIS.
methodsThe subjects consisted of 623 patients with DCIS who underwent sentinel lymph node (SN) biopsy. Of these, 2-mm-sectioned nodes were examined using frozen-section (FS) histology in 338 patients between 2007 and 2009, while 285 underwent OSNA whole node assays between 2009 and 2011. The SN-positivity rate was compared between cohorts, and the characteristics of OSNA-positive DCIS were investigated.
resultsThe OSNA detected more cases of SN metastases than FS histology (12 out of 285, 4.2% vs 1 out of 338, 0.3%). Most of the metastases were micrometastases. The characteristics of high-risk DCIS (i.e., mass formation, size, grade, and comedo) and preoperative breast biopsy (i.e., methods or time to surgery) were not valid for OSNA assay–positive DCIS.
conclusionThe OSNA detects more SN metastases in DCIS than FS histology. Further examination of the primary tumours and follow-up of node-positive DCIS are needed to elucidate the pathogenesis.
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