ArticleJournal of Alzheimer's disease : JAD2012
Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study.
Article in Journal of Alzheimer's disease : JAD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02835716 (Pre-Clinical Alzheimer's), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre-Clinical Alzheimer's (ALZ) Diagnosis (PCD) = Optimum Outcomes (OO)
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Sex differences in Alzheimer's disease: a systematic review of two decades of neuroimaging research.The British journal of radiology · 2026Pooled it
- Altered cerebral blood flow in older adults with Alzheimer's disease: a systematic review.Brain imaging and behavior · 2023Pooled it
- Apolipoprotein E Genotype Moderation of the Association Between Physical Activity and Brain Health. A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion.The Journal of physiology · 2021Trial
- Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.GeroScience · 2025Article
- Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer's disease preclinical phase evaluated by dual-phaseScientific reports · 2024Article
- Prospective Longitudinal Perfusion in Probable Alzheimer's Disease Correlated with Atrophy in Temporal Lobe.Aging and disease · 2024Article
- Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia.Cerebral circulation - cognition and behavior · 2024Article
- Metabolomic Signatures of Alzheimer's Disease Indicate Brain Region-Specific Neurodegenerative Progression.International journal of molecular sciences · 2023Article
- Education reduces cognitive dysfunction in Alzheimer's disease by changing regional cerebral perfusion: An in-vivo arterial spin labeling study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults.Brain imaging and behavior · 2022Article
- Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults.Hippocampus · 2021Article
- Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Entorhinal Perfusion Predicts Future Memory Decline, Neurodegeneration, and White Matter Hyperintensity Progression in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease.Molecular neurodegeneration · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) of older adults at risk for Alzheimer's disease (AD) by virtue of their cognitive (i.e., mild cognitive impairment [MCI]) and/or genetic (i.e., apolipoprotein E [APOE] ε4 allele) status demonstrate divergent brain response patterns during memory encoding across studies. Using arterial spin labeling MRI, we examined the influence of AD risk on resting cerebral blood flow (CBF) as well as the CBF and blood oxygenation level dependent (BOLD) signal response to memory encoding in the medial temporal lobes (MTL) in 45 older adults (29 cognitively normal [14 APOE ε4 carriers and 15 noncarriers]; 16 MCI [8 APOE ε4 carriers, 8 noncarriers]). Risk groups were comparable in terms of mean age, years of education, gender distribution, and vascular risk burden. Individuals at genetic risk for AD by virtue of the APOE ε4 allele demonstrated increased MTL resting state CBF relative to ε4 noncarriers, whereas individuals characterized as MCI showed decreased MTL resting state CBF relative to their cognitively normal peers. For percent change CBF, there was a trend toward a cognitive status by genotype interaction. In the cognitively normal group, there was no difference in percent change CBF based on APOE genotype. In contrast, in the MCI group, APOE ε4 carriers demonstrated significantly greater percent change in CBF relative to ε4 noncarriers. No group differences were found for BOLD response. Findings suggest that abnormal resting state CBF and CBF response to memory encoding may be early indicators of brain dysfunction in individuals at risk for developing AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.