ArticleThe Kaohsiung journal of medical sciences2012
The antinociceptive effect of acetaminophen in a rat model of neuropathic pain.
Article in The Kaohsiung journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Acetaminophen, a new tool for the refinement of the experimental infection of toxoplasmosis in mice.Scientific reports · 2025Article
- Article
- Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference.Pain reports · 2024Article
- Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model.The Korean journal of pain · 2022Article
- Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice.Aging · 2021Article
- Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test.BMC pharmacology & toxicology · 2021Article
- Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing.Journal of pain research · 2021Review
- Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.Scientific reports · 2020Article
- Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice.Aging · 2020Article
- Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats.Pharmacology research & perspectives · 2018Article
- Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Investigation of the Antinociceptive Activity of the Hydroethanolic Extract ofDose-response : a publication of International Hormesis SocietyArticle
- Bone marrow mesenchymal stem cells attenuate pain and modulate peripheral sodium channel activity in a rat model of complex regional pain syndrome type I.Cell transplantationArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen is one of the most popular and widely used analgesics for the treatment of pain and fever but few studies have evaluated its effects on neuropathic pain. This study examined the effect of acetaminophen on thermal hyperalgesia, mechanical and cold allodynia in a rat model of neuropathic pain. Male Sprague-Dawley rats were prepared by tightly ligating the left L5 and L6 spinal nerves to produce a model of neuropathic pain. Sixty neuropathic rats were assigned randomly into six groups. Normal saline and acetaminophen (25, 50, 100, 200 and 300 mg/kg) were administered intraperitoneally to these individual groups. Thermal hyperalgesia, mechanical and cold allodynia were examined at preadministration and at 15, 30, 60, 90, 120, 180, 240 and 360 min after administering the drug. Mechanical allodynia was quantified by measuring the paw withdrawal threshold to stimuli with von Frey filaments. Cold allodynia was quantified by measuring the frequency of foot lift after applying 100% acetone. Thermal hyperalgesia was quantified by measuring the thermal withdrawal threshold. The rotarod performance was measured to detect any drug-induced adverse effects, such as drowsiness. The hepatic and renal adverse effect was also assessed by measuring the serum levels of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen and creatinine. The paw withdrawal thresholds to mechanical stimuli and the thermal withdrawal threshold were increased significantly and withdrawal frequencies to cold stimuli were reduced by acetaminophen administration in a dose-dependent manner. Acetaminophen reduces thermal hyperalgesia, mechanical and cold allodynia in a rat model of neuropathic pain, and might be useful for managing neuropathic pain.
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