ArticleThe Pediatric infectious disease journal2012
Use of the complete blood cell count in early-onset neonatal sepsis.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03694613 (A Pilot Study to Evaluate the Utility of Placental/Umbilical Cord Blood), which is not on this map. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Evaluate the Utility of Placental/Umbilical Cord Blood (PUCB) in Early Onset Neonatal Sepsis (EONS) in Very Low Birth Weight Infants
Who cites it
91 citing papers in PubMed, 277 citations in OpenAlex.
- Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2020Trial
- Population pharmacokinetics of intravenous acyclovir in preterm and term infants.The Pediatric infectious disease journal · 2014Trial
- Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: a five-year experience.PloS one · 2013Trial
- Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity.Nature reviews. Immunology · 2026Review
- Exploratory Hemodynamic and Hematologic Trajectories by Culture Status Among Neonates Evaluated for Infection.Children (Basel, Switzerland) · 2026Article
- Association between the systemic immune-inflammation index within 1 h after birth and the risk of neonatal respiratory distress syndrome in preterm infants.BMC pediatrics · 2026Article
- Is the Neonatal Sepsis Screen More Futile Than Useful in Clinical Practice? Yes.Indian pediatrics · 2026Article
- Hemodynamic Assessment in Newborn Infants With Sepsis: A Prospective Observational Study.Cureus · 2026Article
- Neonatal leucocyte cell population data: reference intervals and relevance for detecting sepsis and necrotizing enterocolitis.Pediatric research · 2026Article
- Implementation of the early-onset sepsis calculator in a tertiary care NICU.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Validation of the ICD-10 Diagnoses of Early-Onset Neonatal Infection in the Danish National Patient Register from 2010 to 2018.Clinical epidemiology · 2026Article
- Transcriptomics-guided serum podoplanin and interpretable machine learning for early risk stratification of necrotizing enterocolitis in preterm infants.Frontiers in immunology · 2026Article
- White blood cell and neutrophil trends in likely early-onset neonatal sepsis: a sex-stratified analysis before and after antibiotic therapy.Frontiers in pediatrics · 2026Article
- Factorial vignettes describe suspected early onset sepsis practice variation in a multicenter NICU antibiotic stewardship collaborative.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Unveiling the Power of Platelet-to-Lymphocyte Ratio as a Game-Changer in Late-Onset Neonatal Sepsis Diagnosis.Children (Basel, Switzerland) · 2025Article
- A neonatal mouse model of meconium peritonitis generated using human meconium slurry.Pediatric research · 2025Article
- Diagnostic Value of Mean Platelet Volume, Neutrophil-to-Lymphocyte Ratio, and Platelet to Lymphocyte Ratio for Late-Onset Neonatal Sepsis.International journal of preventive medicine · 2025Article
- High CRP and white blood cell counts are not reliable indicators of early-onset neonatal infection in full-term infants.Frontiers in pediatrics · 2025Article
- Diagnostic value of procalcitonin and hemocyte parameters in neonates with bloodstream infection: Role of activated hemocyte-related genes.Pediatric discovery · 2024Article
- Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation.EBioMedicine · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEarly-onset sepsis (EOS) is an important cause of morbidity and mortality in neonates, and its diagnosis remains challenging. The complete blood cell count and differential have been previously evaluated as diagnostic tools for EOS in small, single-center reports. We evaluated the diagnostic accuracy of the complete blood cell count and differential in EOS in a large, multicenter population of neonates admitted to the neonatal intensive care unit.
methodsUsing a cohort of 166,092 neonates with suspected EOS with cultures admitted to 293 neonatal intensive care units, we calculated odds ratios and receiver operating characteristic curves for complete blood cell count indices and prediction of a positive culture. We determined sensitivity, specificity and likelihood ratios for various commonly used cutoff values from the complete blood cell count.
resultsLow white blood cell counts, low absolute neutrophil counts and high immature-to-total neutrophil ratios were associated with increasing odds of infection (highest odds ratios: 5.38, 6.84 and 7.97, respectively). Specificity and negative predictive values were high (73.7%-99.9% and >99.8%). However, sensitivities were low (0.3%-54.5%) for all complete blood cell count indices analyzed.
conclusionLow white blood cell count, absolute neutrophil count and high immature-to-total neutrophil ratio were associated with increasing odds of infection, but no complete blood cell count-derived index possesses the sensitivity to rule out reliably EOS in neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.