ArticleMolecular systems biology2012
Asymmetric positive feedback loops reliably control biological responses.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Targeting the 5-HTActa pharmacologica Sinica · 2026Article
- Proximity labelling suggests association of the nonhost receptor PSS1 protein with enzymes of multiple defense pathways in Arabidopsis.Frontiers in plant science · 2025Article
- Shared Mechanisms inPPAR research · 2024Article
- Peroxisome prognostications: Exploring the birth, life, and death of an organelle.The Journal of cell biology · 2020Review
- Differential gene regulatory networks in development and disease.Cellular and molecular life sciences : CMLS · 2018Review
- Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model.BMC systems biology · 2017Article
- Superactivation of AMPA receptors by auxiliary proteins.Nature communications · 2016Article
- Signaling dynamics and peroxisomes.Current opinion in cell biology · 2015Review
- Systems cell biology.The Journal of cell biology · 2014Review
- A design principle underlying the paradoxical roles of E3 ubiquitin ligases.Scientific reports · 2014Article
- An evolutionarily conserved RNase-based mechanism for repression of transcriptional positive autoregulation.Molecular microbiology · 2014Article
- Computational analyses of synergism in small molecular network motifs.PLoS computational biology · 2014Article
- Molecular mechanisms of system responses to novel stimuli are predictable from public data.Nucleic acids research · 2014Article
- Cellular sensory mechanisms for detecting specific fold-changes in extracellular cues.Biophysical journal · 2014Article
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
- Systems approach to developmental biology--designs for robust patterning.IET systems biology · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.