ReviewReproductive biology and endocrinology : RB&E2012
Predicting and preventing ovarian hyperstimulation syndrome (OHSS): the need for individualized not standardized treatment.
Review in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 139 citations in OpenAlex.
- A Personalized Management Approach of OHSS: Development of a Multiphase Prediction Model and Smartphone-Based App.Frontiers in endocrinology · 2022Trial
- Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention.Saudi medical journal · 2018Trial
- Luteinizing hormone change trajectories in gonadotropin-releasing hormone antagonist protocols are associated with assisted reproductive outcomes: results from a retrospective cohort study.Journal of ovarian research · 2026Article
- Ovarian hyperstimulation syndrome with pleural effusion after unassisted pregnancy during a luteal-phase stimulation cycle.F&S reports · 2026Article
- A Woman's Infertility Journey Complicated by Severe Ovarian Hyperstimulation Syndrome - A Case Report.Journal of education & teaching in emergency medicine · 2026Article
- Technical laboratory procedures faced on many oocytes picked up in vitro fertilization cycles.JBRA assisted reproduction · 2025Article
- The Effect of Retinoic Acid and Bevacizumab on Ovarian Hyperstimulation Syndrome.Journal of clinical practice and research · 2025Article
- Exploring gonadotropin dosing effects on MII oocyte retrieval in ovarian stimulation.Journal of assisted reproduction and genetics · 2024Article
- Egg donor self-reports of ovarian hyperstimulation syndrome: severity by trigger type, oocytes retrieved, and prior history.Journal of assisted reproduction and genetics · 2023Article
- Peripheral blood transcriptome analysis of patients with ovarian hyperstimulation syndrome through high-throughput sequencing.Reproductive and developmental medicine · 2023Article
- Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data.PLoS computational biology · 2023Article
- Spontaneous and iatrogenic ovarian hyperstimulation syndrome in the absence of FSHR mutations: a case report of two unexpected cases.BMC medical genomics · 2023Article
- Comparison of bromocriptine and hydroxyethyl starch in the prevention of ovarian hyperstimulation syndrome.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Article
- Family-building and parenting considerations for people with cystic fibrosis.Pediatric pulmonology · 2022Review
- The influence of obesity on incidence of complications in patients hospitalized with ovarian hyperstimulation syndrome.Archives of gynecology and obstetrics · 2022Observational
- Nintedanib Treatment After Ovulation is an Effective Therapeutic Strategy for the Alleviation of Ovarian Hyperstimulation Syndrome (OHSS) in a Mouse Model.Drug design, development and therapy · 2022Article
- Predictive Factors for Recovery Time in Conceived Women Suffering From Moderate to Severe Ovarian Hyperstimulation Syndrome.Frontiers in endocrinology · 2022Article
- Ovarian Hyperstimulation Syndrome (OHSS) requiring Intensive Care Unit (ICU) admission between 1996-2020 in England, Wales, and Northern Ireland.Frontiers in endocrinology · 2022Article
- Why Are the Proportions of In-Vitro Fertilisation Interventions for Same Sex Female Couples Increasing?Healthcare (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian hyperstimulation syndrome (OHSS) is the most serious complication of controlled ovarian stimulation (COS) as part of assisted reproductive technologies (ART). While the safety and efficacy of ART is well established, physicians should always be aware of the risk of OHSS in patients undergoing COS, as it can be fatal. This article will briefly present the pathophysiology of OHSS, including the key role of vascular endothelial growth factor (VEGF), to provide the foundation for an overview of current techniques for the prevention of OHSS. Risk factors and predictive factors for OHSS will be presented, as recognizing these risk factors and individualizing the COS protocol appropriately is the key to the primary prevention of OHSS, as the benefits and risks of each COS strategy vary among individuals. Individualized COS (iCOS) could effectively eradicate OHSS, and the identification of hormonal, functional and genetic markers of ovarian response will facilitate iCOS. However, if iCOS is not properly applied, various preventive measures can be instituted once COS has begun, including cancelling the cycle, coasting, individualizing the human chorionic gonadotropin trigger dose or using a gonadotropin-releasing hormone (GnRH) agonist (for those using a GnRH antagonist protocol), the use of intravenous fluids at the time of oocyte retrieval, and cryopreserving/vitrifying all embryos for subsequent transfer in an unstimulated cycle. Some of these techniques have been widely adopted, despite the scarcity of data from randomized clinical trials to support their use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.