ArticleReproductive biology and endocrinology : RB&E2012
Association of interleukin-18 gene polymorphism with body mass index in women.
Article in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic Review ofInternational journal of molecular sciences · 2024Pooled it
- Review
- Innate-Immunity Genes in Obesity.Journal of personalized medicine · 2021Review
- Association between IL-18 and IL-6 gene polymorphisms and the risk of T1D in Egyptian children.Journal of diabetes and metabolic disorders · 2021Article
- HLA-G14bp ins/del polymorphism and post-transplant weight gain in kidney transplantation: potential implications beyond tolerance.BMC nephrology · 2020Article
- Association of interleukin-18 gene polymorphism and its protein expression with the lower extremity deep venous thrombosis in the chinese han population: A case-control study.Journal of clinical laboratory analysis · 2018Article
- AreBMJ open · 2017Article
- Ischemic stroke susceptibility gene in a Northern Han Chinese population.Neural regeneration research · 2013Article
- Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin (IL)-18 is an important regulator of innate and acquired immune responses and has multiple roles in chronic inflammation and autoimmune disorders. Obesity is characterized by low- grade chronic inflammation. IL-18 has been suggested as an adipogenic cytokine that is associated with excess adiposity. The purpose of this study is to evaluate the relationship between IL-18 gene polymorphisms (-137 G/C and -607 C/A) and obesity.
methodsAll 680 subjects were genotyped for the polymorphisms of IL-18 gene promoters (at positions -137 G/C and -607 C/A) using a polymerase chain reaction (271 cases with BMI ≥25 kg/m² and 409 controls with BMI <25 kg/m²). A chi-square test was used to compare the genotype and allele frequencies between the cases and control populations.
resultsAnalyses of the genotype distributions revealed that IL-18 -607 C/A polymorphism was associated with an increase in body mass index in obese women in the Korean population (chi(2) = 12.301, df = 2, p = 0.015).
conclusionCarriage of the A allele at position -607 in the promoter of the IL-18 gene may have a role in the development of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.