Evidence map›Paper›PMID 22531013›Full record

ArticleImplementation science : IS2012

Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework.

Simon D French, Sally E Green, Denise A O'Connor, Joanne E McKenzie, Jill J Francis, Susan Michie, Rachelle Buchbinder, Peter Schattner, Neil Spike, Jeremy M Grimshaw

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Implementation science : IS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 661 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
661citing papers in PubMed, 20 pooled it
95.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07420881 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Start 4 All - DARE-TB

TypeinterventionalSponsorLiverpool School of Tropical MedicineRan2026 to 2027Enrolled60,000ConditionsTB - TuberculosisArmsNear point of care (NPOC) NAATs, Low-complexity nucleic acid amplification tests (LC-NAATs), LC-NAAT using pooled testing, Computer-Aided Detection (CAD) Chest X-ray (CXR-AI), Culture (reference standard)
NCT07458841 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of the Nurse-led Discharge Interventions in Promoting Hospital Patients' Primary Health Care Outcomes on Discharge: A Proof-of-concept Cluster Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2027Enrolled120ConditionsPrimary HealthcareArmsPrimary healthcare discharge education, specially-designed health education leaflet, Patient discharge package, usual hospital discharge practice
NCT07517471 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Start4All - Start Taking Action for TB Diagnosis SCREEN-TB

TypeinterventionalSponsorLiverpool School of Tropical MedicineRan2026 to 2027Enrolled37,000ConditionsTB - TuberculosisArmsNear point of care (NPOC) NAATs, Low-complexity nucleic acid amplification tests (LC-NAATs), LC-NAAT using pooled testing, Portable Chest X-ray Image Acquisition, Computer-Aided Detection (CAD) Chest X-ray (CXR-AI)
3 · Its place in the literature

Who cites it

661 citing papers in PubMed, 20 syntheses or guidelines pooled it, 1,394 citations in OpenAlex.

  1. Intervention Using Video and Comic Books Targeting Nutritional Outcomes in Children and Adolescents: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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  4. Tailored interventions to address determinants of practice.The Cochrane database of systematic reviews · 2026
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  7. Application of the Knowledge-to-Action framework in translating nutrition and dietetic knowledge into practice: A systematic review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
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  13. Effect of pharmacist care on clinical outcomes and therapy optimization in perioperative settings: A systematic review.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2024
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601 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Simon D FrenchSchool of Public Health and Preventive Medicine, Monash University, Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia. s.french@unimelb.edu.au
Sally E Green
Denise A O'Connor
Joanne E McKenzie
Jill J Francis
Susan Michie
Rachelle Buchbinder
Peter Schattner
Neil Spike
Jeremy M Grimshaw
Monash University · AUCabrini Hospital · AUThe Alfred Hospital · AUUniversity College London · GBUniversity of Aberdeen · GBUniversity of Ottawa · CA

Funding

Chief Scientist Office HSRU2
6 · The paper itself

Abstract

backgroundThere is little systematic operational guidance about how best to develop complex interventions to reduce the gap between practice and evidence. This article is one in a Series of articles documenting the development and use of the Theoretical Domains Framework (TDF) to advance the science of implementation research.

methodsThe intervention was developed considering three main components: theory, evidence, and practical issues. We used a four-step approach, consisting of guiding questions, to direct the choice of the most appropriate components of an implementation intervention: Who needs to do what, differently? Using a theoretical framework, which barriers and enablers need to be addressed? Which intervention components (behaviour change techniques and mode(s) of delivery) could overcome the modifiable barriers and enhance the enablers? And how can behaviour change be measured and understood?

resultsA complex implementation intervention was designed that aimed to improve acute low back pain management in primary care. We used the TDF to identify the barriers and enablers to the uptake of evidence into practice and to guide the choice of intervention components. These components were then combined into a cohesive intervention. The intervention was delivered via two facilitated interactive small group workshops. We also produced a DVD to distribute to all participants in the intervention group. We chose outcome measures in order to assess the mediating mechanisms of behaviour change.

conclusionsWe have illustrated a four-step systematic method for developing an intervention designed to change clinical practice based on a theoretical framework. The method of development provides a systematic framework that could be used by others developing complex implementation interventions. While this framework should be iteratively adjusted and refined to suit other contexts and settings, we believe that the four-step process should be maintained as the primary framework to guide researchers through a comprehensive intervention development process.

Indexed as

Education, Medical, ContinuingEvidence-Based MedicineGuideline AdherencePractice Patterns, Physicians'AustraliaFocus GroupsGeneral PracticeHealth Services ResearchHumansLow Back PainModels, PsychologicalVideodisc Recording

Identifiers

PMID22531013
PMCPMC3443064
OpenAlexW2097859515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.