ReviewNeural plasticity2012
Erasing synapses in sleep: is it time to be SHY?
Review in Neural plasticity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Frontal synaptic plasticity: A new key to homeostatic sleep regulation.Neural regeneration research · 2026Article
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Mapping the Neural Basis of Wake Onset Regularity and Its Effects on Sleep Quality and Positive Affect.Clocks & sleep · 2025Article
- Review
- Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024Article
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- Article
- Putative roles for homeostatic plasticity in epileptogenesis.Epilepsia · 2023Review
- REM sleep promotes bidirectional plasticity in developing visual cortexNeurobiology of sleep and circadian rhythms · 2022Article
- Article
- The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex.Molecular neurobiology · 2022Article
- Cognitive functions and underlying parameters of human brain physiology are associated with chronotype.Nature communications · 2021Article
- The overfitted brain: Dreams evolved to assist generalization.Patterns (New York, N.Y.) · 2021Review
- Challenging sleep homeostasis.Neurobiology of sleep and circadian rhythms · 2021Article
- Sleep Promotes Downward Firing Rate Homeostasis.Neuron · 2021Article
- The Ontogenesis of Mammalian Sleep: Form and Function.Current sleep medicine reports · 2020Article
- Is Sleep Disruption a Cause or Consequence of Alzheimer's Disease? Reviewing Its Possible Role as a Biomarker.International journal of molecular sciences · 2020Review
- Neurochemical mechanisms for memory processing during sleep: basic findings in humans and neuropsychiatric implications.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Article
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Abstract
Converging lines of evidence strongly support a role for sleep in brain plasticity. An elegant idea that may explain how sleep accomplishes this role is the "synaptic homeostasis hypothesis (SHY)." According to SHY, sleep promotes net synaptic weakening which offsets net synaptic strengthening that occurs during wakefulness. SHY is intuitively appealing because it relates the homeostatic regulation of sleep to an important function (synaptic plasticity). SHY has also received important experimental support from recent studies in Drosophila melanogaster. There remain, however, a number of unanswered questions about SHY. What is the cellular mechanism governing SHY? How does it fit with what we know about plasticity mechanisms in the brain? In this review, I discuss the evidence and theory of SHY in the context of what is known about Hebbian and non-Hebbian synaptic plasticity. I conclude that while SHY remains an elegant idea, the underlying mechanisms are mysterious and its functional significance unknown.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.