ArticlePloS one2012
Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Involvement of CD146 in theInfection and immunity · 2025Article
- Clinical characteristics and prognostic factors of pulmonary and extrapulmonary cryptococcosis.BMC infectious diseases · 2024Article
- A multi-arm, parallel, preclinical study investigating the potential benefits of acetazolamide, candesartan, and triciribine in combination with fluconazole for the treatment of cryptococcal meningoencephalitis.European journal of pharmacology · 2023Article
- Cerebral malaria - modelling interactions at the blood-brain barrier in vitro.Disease models & mechanisms · 2022Review
- Quantitative analysis reveals internalisation of Cryptococcus neoformans by brain endothelial cells in vivo.Cellular microbiology · 2021Article
- Mechanisms of fungal dissemination.Cellular and molecular life sciences : CMLS · 2021Review
- Fine Particulate Matter (PMFrontiers in microbiology · 2020Article
- An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System.Current protocols in microbiology · 2019Article
- Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH.PLoS pathogens · 2018Article
- Neuro-Immune Mechanisms of Anti-Cryptococcal Protection.Journal of fungi (Basel, Switzerland) · 2017Review
- Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans.CNS neuroscience & therapeutics · 2017Article
- Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.mBio · 2017Article
- Fungal Infection in the Brain: What We Learned from Intravital Imaging.Frontiers in immunology · 2016Review
- Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome.Frontiers in microbiology · 2016Review
- From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system.Current opinion in microbiology · 2015Review
- Dancing cheek to cheek: Cryptococcus neoformans and phagocytes.SpringerPlus · 2015Review
- Article
- The intracellular life of Cryptococcus neoformans.Annual review of pathology · 2014Review
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cryptococcosis is a life-threatening fungal disease with a high rate of mortality among HIV/AIDS patients across the world. The ability to penetrate the blood-brain barrier (BBB) is central to the pathogenesis of cryptococcosis, but the way in which this occurs remains unclear. Here we use both mouse and human brain derived endothelial cells (bEnd3 and hCMEC/D3) to accurately quantify fungal uptake and survival within brain endothelial cells. Our data indicate that the adherence and internalisation of cryptococci by brain microvascular endothelial cells is an infrequent event involving small numbers of cryptococcal yeast cells. Interestingly, this process requires neither active signalling from the fungus nor the presence of the fungal capsule. Thus entry into brain microvascular endothelial cells is most likely a passive event that occurs following 'trapping' within capillary beds of the BBB.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.