ArticlePloS one2012
Seasonal changes in patterns of gene expression in avian song control brain regions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Response to geographic song variation predicts differential gene expression in the blood of a songbird.iScience · 2026Article
- Parenchymal precursor cells act in concert with canonical neural progenitors to facilitate neural circuit recovery following neuronal loss.bioRxiv : the preprint server for biology · 2026Article
- From silence to song: Testosterone triggers extensive transcriptional changes in the female canary HVC.Journal of neuroendocrinology · 2025Article
- A mammalian messenger RNA sex determination method from humpback whale (Royal Society open science · 2022Article
- Understanding hippocampal neural plasticity in captivity: Unique contributions of spatial specialists.Learning & behavior · 2022Review
- Unraveling the Role of Thyroid Hormones in Seasonal Neuroplasticity in European Starlings (Frontiers in molecular neuroscience · 2022Article
- Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail.Frontiers in physiology · 2022Article
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The neurogenomic transition from territory establishment to parenting in a territorial female songbird.BMC genomics · 2019Article
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds.Scientific reports · 2019Article
- Curation of microarray oligonucleotides and corresponding ESTs/cDNAs used for gene expression analysis in zebra finches.BMC research notes · 2018Article
- The constitutive differential transcriptome of a brain circuit for vocal learning.BMC genomics · 2018Article
- Androgen and estrogen sensitivity of bird song: a comparative view on gene regulatory levels.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Advantages of comparative studies in songbirds to understand the neural basis of sensorimotor integration.Journal of neurophysiology · 2017Review
- Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.Nature communications · 2017Article
- Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit.BMC genomics · 2015Article
- Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.Genes, brain, and behavior · 2015Article
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
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Authors and funding
12 authors.
Funding
Abstract
Photoperiod and hormonal cues drive dramatic seasonal changes in structure and function of the avian song control system. Little is known, however, about the patterns of gene expression associated with seasonal changes. Here we address this issue by altering the hormonal and photoperiodic conditions in seasonally-breeding Gambel's white-crowned sparrows and extracting RNA from the telencephalic song control nuclei HVC and RA across multiple time points that capture different stages of growth and regression. We chose HVC and RA because while both nuclei change in volume across seasons, the cellular mechanisms underlying these changes differ. We thus hypothesized that different genes would be expressed between HVC and RA. We tested this by using the extracted RNA to perform a cDNA microarray hybridization developed by the SoNG initiative. We then validated these results using qRT-PCR. We found that 363 genes varied by more than 1.5 fold (>log(2) 0.585) in expression in HVC and/or RA. Supporting our hypothesis, only 59 of these 363 genes were found to vary in both nuclei, while 132 gene expression changes were HVC specific and 172 were RA specific. We then assigned many of these genes to functional categories relevant to the different mechanisms underlying seasonal change in HVC and RA, including neurogenesis, apoptosis, cell growth, dendrite arborization and axonal growth, angiogenesis, endocrinology, growth factors, and electrophysiology. This revealed categorical differences in the kinds of genes regulated in HVC and RA. These results show that different molecular programs underlie seasonal changes in HVC and RA, and that gene expression is time specific across different reproductive conditions. Our results provide insights into the complex molecular pathways that underlie adult neural plasticity.
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