ArticlePloS one2012
Phenotypic diversification is associated with host-induced transposon derepression in the sudden oak death pathogen Phytophthora ramorum.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Asexual Evolution and Forest Conditions Drive Genetic Parallelism inMicroorganisms · 2020Article
- Characterization of Two Satellite DNA Families in the Genome of the Oomycete Plant PathogenFrontiers in genetics · 2020Article
- Molecular assays to detect the presence and viability of Phytophthora ramorum and Grosmannia clavigera.PloS one · 2020Article
- Characterization of phenotypic variation and genome aberrations observed among Phytophthora ramorum isolates from diverse hosts.BMC genomics · 2018Article
- Phytophthora megakarya and P. palmivora, closely related causal agents of cacao black pod rot, underwent increases in genome sizes and gene numbers by different mechanisms.Genome biology and evolution · 2017Article
- Host-induced aneuploidy and phenotypic diversification in the Sudden Oak Death pathogen Phytophthora ramorum.BMC genomics · 2016Article
- Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.BMC genomics · 2015Article
- Transcriptome analysis of the white pine blister rust pathogen Cronartium ribicola: de novo assembly, expression profiling, and identification of candidate effectors.BMC genomics · 2015Article
- The Top 10 oomycete pathogens in molecular plant pathology.Molecular plant pathology · 2015Review
- Epigenetic control of effector gene expression in the plant pathogenic fungus Leptosphaeria maculans.PLoS genetics · 2014Article
- Epigenetic control of effectors in plant pathogens.Frontiers in plant science · 2014Article
- Phenotypic diversification by gene silencing in Phytophthora plant pathogens.Communicative & integrative biology · 2013Review
- Scaling up from greenhouse resistance to fitness in the field for a host of an emerging forest disease.Evolutionary applications · 2013Article
- MITEs in the promoters of effector genes allow prediction of novel virulence genes in Fusarium oxysporum.BMC genomics · 2013Article
- Conserved loci of leaf and stem rust fungi of wheat share synteny interrupted by lineage-specific influx of repeat elements.BMC genomics · 2013Article
- Dynamics and innovations within oomycete genomes: insights into biology, pathology, and evolution.Eukaryotic cell · 2012Review
- Sudden oak death: interactions of the exotic oomycete Phytophthora ramorum with naïve North American hosts.Eukaryotic cell · 2012Review
- Temperature-dependent growth of Geomyces destructans, the fungus that causes bat white-nose syndrome.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The oomycete pathogen Phytophthora ramorum is responsible for sudden oak death (SOD) in California coastal forests. P. ramorum is a generalist pathogen with over 100 known host species. Three or four closely related genotypes of P. ramorum (from a single lineage) were originally introduced in California forests and the pathogen reproduces clonally. Because of this the genetic diversity of P. ramorum is extremely low in Californian forests. However, P. ramorum shows diverse phenotypic variation in colony morphology, colony senescence, and virulence. In this study, we show that phenotypic variation among isolates is associated with the host species from which the microbe was originally cultured. Microarray global mRNA profiling detected derepression of transposable elements (TEs) and down-regulation of crinkler effector homologs (CRNs) in the majority of isolates originating from coast live oak (Quercus agrifolia), but this expression pattern was not observed in isolates from California bay laurel (Umbellularia californica). In some instances, oak and bay laurel isolates originating from the same geographic location had identical genotypes based on multilocus simples sequence repeat (SSR) marker analysis but had different phenotypes. Expression levels of the two marker genes analyzed by quantitative reverse transcription PCR were correlated with originating host species, but not with multilocus genotypes. Because oak is a nontransmissive dead-end host for P. ramorum, our observations are congruent with an epi-transposon hypothesis; that is, physiological stress is triggered on P. ramorum while colonizing oak stems and disrupts epigenetic silencing of TEs. This then results in TE reactivation and possibly genome diversification without significant epidemiological consequences. We propose the P. ramorum-oak host system in California forests as an ad hoc model for epi-transposon mediated diversification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.