ArticlePloS one2012
Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- BullFish: Software for an automated stepwise analysis of positional and postural kinematics of zebrafish locomotion.iScience · 2026Article
- Different Colours, Different Outcomes: Tank Colour Shapes Larval Survival, Growth, and Endocrine Response inAnimals : an open access journal from MDPI · 2026Article
- Dissecting Larval Zebrafish Hunting using Deep Reinforcement Learning Trained RNN Agents.Proceedings of the ... Conference on Cognitive Computational Neuroscience · 2026Article
- Water temperature modulates multidimensional plastic responses to water flow during the ontogeny of a neotropical fish (Frontiers in cell and developmental biology · 2025Article
- A Zebrafish Mutant in the Extracellular Matrix Protein GeneAnimals : an open access journal from MDPI · 2023Article
- Optimizing assays of zebrafish larvae swimming performance for drug discovery.Expert opinion on drug discovery · 2023Review
- Integration of Metabolomics and Transcriptomics to Reveal the Metabolic Characteristics of Exercise-Improved Bone Mass.Nutrients · 2023Article
- Juvenile zebrafish (Danio rerio) are able to recover from lordosis.Scientific reports · 2022Article
- Review
- A Baseline for Skeletal Investigations in Medaka (Frontiers in endocrinology · 2022Review
- Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration.Histochemistry and cell biology · 2020Review
- Review
- Zebrafish: An Emerging Model for Orthopedic Research.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Physiological Effects of Water Flow Induced Swimming Exercise in SeabreamFrontiers in physiology · 2020Article
- Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.Journal of the Royal Society, Interface · 2019Article
- Using zebrafish to study skeletal genomics.Bone · 2019Review
- A novel nonosteocytic regulatory mechanism of bone modeling.PLoS biology · 2019Article
- Evolution of caudal fin ray development and caudal fin hypural diastema complex in spotted gar, teleosts, and other neopterygian fishes.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Skeletal development in the heterocercal caudal fin of spotted gar (lepisosteus oculatus) and other lepisosteiformes.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish larvae experience many environmental challenges during development such as variation in water velocity, food availability and predation. The rapid development of structures involved in feeding, respiration and swimming increases the chance of survival. It has been hypothesized that mechanical loading induced by muscle forces plays a role in prioritizing the development of these structures. Mechanical loading by muscle forces has been shown to affect larval and embryonic bone development in vertebrates, but these investigations were limited to the appendicular skeleton. To explore the role of mechanical load during chondrogenesis and osteogenesis of the cranial, axial and appendicular skeleton, we subjected zebrafish larvae to swim-training, which increases physical exercise levels and presumably also mechanical loads, from 5 until 14 days post fertilization. Here we show that an increased swimming activity accelerated growth, chondrogenesis and osteogenesis during larval development in zebrafish. Interestingly, swim-training accelerated both perichondral and intramembranous ossification. Furthermore, swim-training prioritized the formation of cartilage and bone structures in the head and tail region as well as the formation of elements in the anal and dorsal fins. This suggests that an increased swimming activity prioritized the development of structures which play an important role in swimming and thereby increasing the chance of survival in an environment where water velocity increases. Our study is the first to show that already during early zebrafish larval development, skeletal tissue in the cranial, axial and appendicular skeleton is competent to respond to swim-training due to increased water velocities. It demonstrates that changes in water flow conditions can result into significant spatio-temporal changes in skeletogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.