ArticleFrontiers in pharmacology2012
Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact.
Article in Frontiers in pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications.Journal of neurochemistry · 2025Review
- Chemogenetics with PSAMGene therapy · 2025Article
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures.International journal of molecular sciences · 2021Article
- Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington's Disease.Frontiers in cellular neuroscience · 2021Review
- Muscles of Breathing: Development, Function, and Patterns of Activation.Comprehensive Physiology · 2019Review
- Thalamic inhibitory circuits and network activity development.Brain research · 2019Review
- Progesterone Actions During Central Nervous System Development.Frontiers in neuroscience · 2019Review
- Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies.Epilepsia open · 2018Article
- Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind.Brain research · 2018Review
- Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.Hippocampus · 2018Article
- Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.Frontiers in synaptic neuroscience · 2018Article
- The Effects of GABAergic Polarity Changes on Episodic Neural Network Activity in Developing Neural Systems.Frontiers in computational neuroscience · 2017Article
- Reality of Inhibitory GABA in Neonatal Brain: Time to Rewrite the Textbooks?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- GABA and glycine in the developing brain.The journal of physiological sciences : JPS · 2016Review
- Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.CNS neuroscience & therapeutics · 2016Article
- Chandelier Cells in Functional and Dysfunctional Neural Circuits.Frontiers in neural circuits · 2016Review
- Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices.PloS one · 2016Article
- Article
- Depolarizing GABA and developmental epilepsies.CNS neuroscience & therapeutics · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of the excitatory action of GABA during early development is based on data obtained mainly in brain slice recordings. However, in vivo measurements as well as observations made in intact hippocampal preparations indicate that GABA is in fact inhibitory in rodents at early neonatal stages. The apparent excitatory action of GABA seems to stem from cellular injury due to the slicing procedure, which leads to accumulation of intracellular Cl(-) in injured neurons. This procedural artifact was shown to be attenuated through various manipulations such as addition of energy substrates more relevant to the in vivo situation. These observations question the very concept of excitatory GABA in immature neuronal networks.
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Registered trials
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