ArticleWorld journal of gastroenterology2012
A population-based cohort study of symptomatic gallstone disease in diabetic patients.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 23 citations in OpenAlex.
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- Association between hepatic steatosis index and gallstones in US adults: A cross-sectional study of NHANES 2017-2020.Medicine · 2026Article
- The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study.Clinics (Sao Paulo, Brazil) · 2024Article
- Waist-to-height ratio for the prediction of gallstone disease among different obesity indicators.Obesity science & practice · 2023Article
- The association between diabetes and gallstones: a nationwide population-based cohort study.Przeglad gastroenterologiczny · 2023Article
- Association between metabolic syndrome and incidence of cholelithiasis in the Korean population.Journal of gastroenterology and hepatology · 2021Article
- Association Between Type I and II Diabetes With Gallbladder Stone Disease.Frontiers in endocrinology · 2018Article
- The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.Scientific reports · 2016Article
- Epidemiology, management, and economic evaluation of screening of gallstone disease among type 2 diabetics: A systematic review.World journal of clinical cases · 2015Review
- Prevalence of gallstone disease in patients with type 2 diabetes and the risk factors in North Indian population: a case control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014Article
- Is there an association between type 1 diabetes in children and gallbladder stones formation?Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the prevalence of gallstone disease (GSD) and to evaluate the risk of symptomatic GSD among diabetic patients.
methodsThe study was conducted by analyzing the National Health Research Institutes (NHRI) dataset of ambulatory care patients, inpatient claims, and the updated registry of beneficiaries from 2000 to 2008. A total of 615,532 diabetic patients without a prior history of hospital treatment or ambulatory care visits for symptomatic GSD were identified in the year 2000. Age- and gender-matched control individuals free from both GSD and diabetes from 1997 to 1999 were randomly selected from the NHIR database (n = 614,871). The incidence densities of symptomatic GSD were estimated according to the subjects' diabetic status. The distributions of age, gender, occupation, income, and residential area urbanization were compared between diabetic patients and control subjects using Cox proportion hazards models. Differences between the rates of selected comorbidities were also assessed in the two groups.
resultsOverall, 60,734 diabetic patients and 48,116 control patients developed symptomatic GSD and underwent operations, resulting in cumulative operation rates of 9.87% and 7.83%, respectively. The age and gender distributions of both groups were similar, with a mean age of 60 years and a predominance of females. The diabetic group had a significantly higher prevalence of all comorbidities of interest. A higher incidence of symptomatic GSD was observed in females than in males in both groups. In the control group, females under the age of 64 had a significantly higher incidence of GSD than the corresponding males, but this difference was reduced with increasing age. The cumulative incidences of operations for symptomatic GSD in the diabetic and control groups were 13.06 and 9.52 cases per 1000 person-years, respectively. Diabetic men exhibited a higher incidence of operations for symptomatic GSD than did their counterparts in the control group (12.35 vs 8.75 cases per 1000 person-years).
conclusionThe association of diabetes with increased symptomatic GSD may provide insight to the treatment or management of diabetes in clinical settings.
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